Lineage-Restricted Expression of Bone Morphogenetic Protein Genes in Human Hematopoietic Cell Lines
To explore the possibility that bone morphogenetic proteins (BMPs) are autocrine/paracrine regulators of hematopoietic differentiation and function, we screened a panel of human cell lines encompassing the hematopoietic lineages for expression of members of this family of genes. Expression of BMP-2,...
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| Veröffentlicht in: | Blood cells, molecules, & diseases molecules, & diseases, 1999-12, Vol.25 (6), p.310-323 |
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| creator | Detmer, Kristina Steele, Timothy A Shoop, Mark A Dannawi, Hassan |
| description | To explore the possibility that bone morphogenetic proteins (BMPs) are autocrine/paracrine regulators of hematopoietic differentiation and function, we screened a panel of human cell lines encompassing the hematopoietic lineages for expression of members of this family of genes. Expression of BMP-2, BMP-4, BMP-6, BMP-7, Growth and Differentiation Factor-1 (GDF-1), Placental Bone Morphogenetic Protein (PLAB), and Transforming Growth Factor-β3 (TGF-β3) was detected in one or more cell lines. BMP-2, BMP-4, BMP-7, and TGF-β3 expression was also found in normal hematopoietic tissue. Expression of BMP-5 and BMP-8 was not seen. Lineage-restricted patterns of expression were found for BMP-4 (T-lymphoid), BMP-7 (lymphoid), PLAB (macrophage/monocyte), and GDF-1 (myeloid). Expression of BMP-2, GDF-1, and PLAB could be modulated by treatment with differentiating agents. Marked variations in the levels of BMP-4, BMP-7, and PLAB expression were encountered, indicating that disorders in BMP signaling pathways may play a role in the development of hematopoietic neoplasia. |
| doi_str_mv | 10.1006/bcmd.1999.0259 |
| format | Article |
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Expression of BMP-2, BMP-4, BMP-6, BMP-7, Growth and Differentiation Factor-1 (GDF-1), Placental Bone Morphogenetic Protein (PLAB), and Transforming Growth Factor-β3 (TGF-β3) was detected in one or more cell lines. BMP-2, BMP-4, BMP-7, and TGF-β3 expression was also found in normal hematopoietic tissue. Expression of BMP-5 and BMP-8 was not seen. Lineage-restricted patterns of expression were found for BMP-4 (T-lymphoid), BMP-7 (lymphoid), PLAB (macrophage/monocyte), and GDF-1 (myeloid). Expression of BMP-2, GDF-1, and PLAB could be modulated by treatment with differentiating agents. Marked variations in the levels of BMP-4, BMP-7, and PLAB expression were encountered, indicating that disorders in BMP signaling pathways may play a role in the development of hematopoietic neoplasia.</description><identifier>ISSN: 1079-9796</identifier><identifier>EISSN: 1096-0961</identifier><identifier>DOI: 10.1006/bcmd.1999.0259</identifier><identifier>PMID: 10660478</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Bone Marrow Cells - chemistry ; Bone Marrow Cells - physiology ; Bone Morphogenetic Protein 2 ; Bone Morphogenetic Protein 4 ; Bone Morphogenetic Protein 5 ; Bone Morphogenetic Protein 6 ; Bone Morphogenetic Protein 7 ; Bone Morphogenetic Proteins - genetics ; Bone Morphogenetic Proteins - physiology ; bone morphogenetic proteins, lineage-restricted expression, hematopoiesis, differentiation, hematopoietic cell lines, neoplasia ; Cell Differentiation - drug effects ; Cell Differentiation - physiology ; Cell Lineage - drug effects ; Cell Lineage - genetics ; Cell Lineage - physiology ; Cytokines ; Gene Expression ; Gene Expression Regulation ; Growth Differentiation Factor 1 ; Growth Differentiation Factor 15 ; Growth Substances - genetics ; Growth Substances - physiology ; Hematopoietic Stem Cells - metabolism ; Hematopoietic Stem Cells - physiology ; Humans ; Intercellular Signaling Peptides and Proteins ; Macrophages - chemistry ; Macrophages - physiology ; Monocytes - chemistry ; Monocytes - physiology ; Nerve Tissue Proteins - genetics ; Nerve Tissue Proteins - physiology ; Pregnancy Proteins - genetics ; Pregnancy Proteins - physiology ; Transforming Growth Factor beta - genetics ; Transforming Growth Factor beta - physiology ; Tumor Cells, Cultured - chemistry ; Tumor Cells, Cultured - physiology</subject><ispartof>Blood cells, molecules, & diseases, 1999-12, Vol.25 (6), p.310-323</ispartof><rights>1999 Academic Press</rights><rights>Copyright 1999 Academic Press.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c340t-9cd24aaed2ebe1ca80398a20dae9ee700bf27dfb96818fe32224660fffc7681f3</citedby><cites>FETCH-LOGICAL-c340t-9cd24aaed2ebe1ca80398a20dae9ee700bf27dfb96818fe32224660fffc7681f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1079979699902590$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10660478$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Detmer, Kristina</creatorcontrib><creatorcontrib>Steele, Timothy A</creatorcontrib><creatorcontrib>Shoop, Mark A</creatorcontrib><creatorcontrib>Dannawi, Hassan</creatorcontrib><title>Lineage-Restricted Expression of Bone Morphogenetic Protein Genes in Human Hematopoietic Cell Lines</title><title>Blood cells, molecules, & diseases</title><addtitle>Blood Cells Mol Dis</addtitle><description>To explore the possibility that bone morphogenetic proteins (BMPs) are autocrine/paracrine regulators of hematopoietic differentiation and function, we screened a panel of human cell lines encompassing the hematopoietic lineages for expression of members of this family of genes. Expression of BMP-2, BMP-4, BMP-6, BMP-7, Growth and Differentiation Factor-1 (GDF-1), Placental Bone Morphogenetic Protein (PLAB), and Transforming Growth Factor-β3 (TGF-β3) was detected in one or more cell lines. BMP-2, BMP-4, BMP-7, and TGF-β3 expression was also found in normal hematopoietic tissue. Expression of BMP-5 and BMP-8 was not seen. Lineage-restricted patterns of expression were found for BMP-4 (T-lymphoid), BMP-7 (lymphoid), PLAB (macrophage/monocyte), and GDF-1 (myeloid). Expression of BMP-2, GDF-1, and PLAB could be modulated by treatment with differentiating agents. Marked variations in the levels of BMP-4, BMP-7, and PLAB expression were encountered, indicating that disorders in BMP signaling pathways may play a role in the development of hematopoietic neoplasia.</description><subject>Bone Marrow Cells - chemistry</subject><subject>Bone Marrow Cells - physiology</subject><subject>Bone Morphogenetic Protein 2</subject><subject>Bone Morphogenetic Protein 4</subject><subject>Bone Morphogenetic Protein 5</subject><subject>Bone Morphogenetic Protein 6</subject><subject>Bone Morphogenetic Protein 7</subject><subject>Bone Morphogenetic Proteins - genetics</subject><subject>Bone Morphogenetic Proteins - physiology</subject><subject>bone morphogenetic proteins, lineage-restricted expression, hematopoiesis, differentiation, hematopoietic cell lines, neoplasia</subject><subject>Cell Differentiation - drug effects</subject><subject>Cell Differentiation - physiology</subject><subject>Cell Lineage - drug effects</subject><subject>Cell Lineage - genetics</subject><subject>Cell Lineage - physiology</subject><subject>Cytokines</subject><subject>Gene Expression</subject><subject>Gene Expression Regulation</subject><subject>Growth Differentiation Factor 1</subject><subject>Growth Differentiation Factor 15</subject><subject>Growth Substances - genetics</subject><subject>Growth Substances - physiology</subject><subject>Hematopoietic Stem Cells - metabolism</subject><subject>Hematopoietic Stem Cells - physiology</subject><subject>Humans</subject><subject>Intercellular Signaling Peptides and Proteins</subject><subject>Macrophages - chemistry</subject><subject>Macrophages - physiology</subject><subject>Monocytes - chemistry</subject><subject>Monocytes - physiology</subject><subject>Nerve Tissue Proteins - genetics</subject><subject>Nerve Tissue Proteins - physiology</subject><subject>Pregnancy Proteins - genetics</subject><subject>Pregnancy Proteins - physiology</subject><subject>Transforming Growth Factor beta - genetics</subject><subject>Transforming Growth Factor beta - physiology</subject><subject>Tumor Cells, Cultured - chemistry</subject><subject>Tumor Cells, Cultured - physiology</subject><issn>1079-9796</issn><issn>1096-0961</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMFPwyAUxonRuDm9ejQ9eesEWmk56jI3kxmN0TOh8JiYtVRojf73UruDFw_Ae-T3vrzvQ-ic4DnBmF1VqtZzwjmfY3rND9CUYM7SeMjhUBc85QVnE3QSwjvGmBBeHqMJwYzhvCinSG1sA3IL6TOEzlvVgU6WX62HEKxrEmeSW9dA8uB8--a20EBnVfLkXQe2SVaxD0ks1n0t4w217Fzr7C-0gN0uGdTDKToychfgbP_O0Ovd8mWxTjePq_vFzSZVWY67lCtNcylBU6iAKFnijJeSYi2BAxQYV4YW2lSclaQ0kFFK82jDGKOK-GWyGbocdVvvPvroR9Q2qLiGbMD1QTCe05LleQTnI6i8C8GDEa23tfTfgmAxxCqGWMUQqxhijQMXe-W-qkH_wcccI1COAER_nxa8CMpCo0BbD6oT2tn_tH8AxhSIWw</recordid><startdate>199912</startdate><enddate>199912</enddate><creator>Detmer, Kristina</creator><creator>Steele, Timothy A</creator><creator>Shoop, Mark A</creator><creator>Dannawi, Hassan</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199912</creationdate><title>Lineage-Restricted Expression of Bone Morphogenetic Protein Genes in Human Hematopoietic Cell Lines</title><author>Detmer, Kristina ; Steele, Timothy A ; Shoop, Mark A ; Dannawi, Hassan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c340t-9cd24aaed2ebe1ca80398a20dae9ee700bf27dfb96818fe32224660fffc7681f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Bone Marrow Cells - chemistry</topic><topic>Bone Marrow Cells - physiology</topic><topic>Bone Morphogenetic Protein 2</topic><topic>Bone Morphogenetic Protein 4</topic><topic>Bone Morphogenetic Protein 5</topic><topic>Bone Morphogenetic Protein 6</topic><topic>Bone Morphogenetic Protein 7</topic><topic>Bone Morphogenetic Proteins - genetics</topic><topic>Bone Morphogenetic Proteins - physiology</topic><topic>bone morphogenetic proteins, lineage-restricted expression, hematopoiesis, differentiation, hematopoietic cell lines, neoplasia</topic><topic>Cell Differentiation - drug effects</topic><topic>Cell Differentiation - physiology</topic><topic>Cell Lineage - drug effects</topic><topic>Cell Lineage - genetics</topic><topic>Cell Lineage - physiology</topic><topic>Cytokines</topic><topic>Gene Expression</topic><topic>Gene Expression Regulation</topic><topic>Growth Differentiation Factor 1</topic><topic>Growth Differentiation Factor 15</topic><topic>Growth Substances - genetics</topic><topic>Growth Substances - physiology</topic><topic>Hematopoietic Stem Cells - metabolism</topic><topic>Hematopoietic Stem Cells - physiology</topic><topic>Humans</topic><topic>Intercellular Signaling Peptides and Proteins</topic><topic>Macrophages - chemistry</topic><topic>Macrophages - physiology</topic><topic>Monocytes - chemistry</topic><topic>Monocytes - physiology</topic><topic>Nerve Tissue Proteins - genetics</topic><topic>Nerve Tissue Proteins - physiology</topic><topic>Pregnancy Proteins - genetics</topic><topic>Pregnancy Proteins - physiology</topic><topic>Transforming Growth Factor beta - genetics</topic><topic>Transforming Growth Factor beta - physiology</topic><topic>Tumor Cells, Cultured - chemistry</topic><topic>Tumor Cells, Cultured - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Detmer, Kristina</creatorcontrib><creatorcontrib>Steele, Timothy A</creatorcontrib><creatorcontrib>Shoop, Mark A</creatorcontrib><creatorcontrib>Dannawi, Hassan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Blood cells, molecules, & diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Detmer, Kristina</au><au>Steele, Timothy A</au><au>Shoop, Mark A</au><au>Dannawi, Hassan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lineage-Restricted Expression of Bone Morphogenetic Protein Genes in Human Hematopoietic Cell Lines</atitle><jtitle>Blood cells, molecules, & diseases</jtitle><addtitle>Blood Cells Mol Dis</addtitle><date>1999-12</date><risdate>1999</risdate><volume>25</volume><issue>6</issue><spage>310</spage><epage>323</epage><pages>310-323</pages><issn>1079-9796</issn><eissn>1096-0961</eissn><abstract>To explore the possibility that bone morphogenetic proteins (BMPs) are autocrine/paracrine regulators of hematopoietic differentiation and function, we screened a panel of human cell lines encompassing the hematopoietic lineages for expression of members of this family of genes. Expression of BMP-2, BMP-4, BMP-6, BMP-7, Growth and Differentiation Factor-1 (GDF-1), Placental Bone Morphogenetic Protein (PLAB), and Transforming Growth Factor-β3 (TGF-β3) was detected in one or more cell lines. BMP-2, BMP-4, BMP-7, and TGF-β3 expression was also found in normal hematopoietic tissue. Expression of BMP-5 and BMP-8 was not seen. Lineage-restricted patterns of expression were found for BMP-4 (T-lymphoid), BMP-7 (lymphoid), PLAB (macrophage/monocyte), and GDF-1 (myeloid). Expression of BMP-2, GDF-1, and PLAB could be modulated by treatment with differentiating agents. Marked variations in the levels of BMP-4, BMP-7, and PLAB expression were encountered, indicating that disorders in BMP signaling pathways may play a role in the development of hematopoietic neoplasia.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>10660478</pmid><doi>10.1006/bcmd.1999.0259</doi><tpages>14</tpages></addata></record> |
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| subjects | Bone Marrow Cells - chemistry Bone Marrow Cells - physiology Bone Morphogenetic Protein 2 Bone Morphogenetic Protein 4 Bone Morphogenetic Protein 5 Bone Morphogenetic Protein 6 Bone Morphogenetic Protein 7 Bone Morphogenetic Proteins - genetics Bone Morphogenetic Proteins - physiology bone morphogenetic proteins, lineage-restricted expression, hematopoiesis, differentiation, hematopoietic cell lines, neoplasia Cell Differentiation - drug effects Cell Differentiation - physiology Cell Lineage - drug effects Cell Lineage - genetics Cell Lineage - physiology Cytokines Gene Expression Gene Expression Regulation Growth Differentiation Factor 1 Growth Differentiation Factor 15 Growth Substances - genetics Growth Substances - physiology Hematopoietic Stem Cells - metabolism Hematopoietic Stem Cells - physiology Humans Intercellular Signaling Peptides and Proteins Macrophages - chemistry Macrophages - physiology Monocytes - chemistry Monocytes - physiology Nerve Tissue Proteins - genetics Nerve Tissue Proteins - physiology Pregnancy Proteins - genetics Pregnancy Proteins - physiology Transforming Growth Factor beta - genetics Transforming Growth Factor beta - physiology Tumor Cells, Cultured - chemistry Tumor Cells, Cultured - physiology |
| title | Lineage-Restricted Expression of Bone Morphogenetic Protein Genes in Human Hematopoietic Cell Lines |
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