Anticonvulsant activity of analogues of acetazolamide

The anticonvulsant activity of 5-tertbutyloxycarbonylamido-1,3,4-thiadiazole-2-sulfonamide (BH 2ats) and 5-amino-1,3,4-thiadiazole-2-sulfonamide (Hats) was compared in mice, to that of acetazolamide (H 2acm). These compounds exhibit potent anticonvulsant activity and low minimal motor impairment.

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Bibliographische Detailangaben
Veröffentlicht in:	Farmaco (Società chimica italiana : 1989) 1999-11, Vol.54 (11), p.838-841
Hauptverfasser:	Chufán, E.E, Pedregosa, J.C, Baldini, O.N, Bruno-Blanch, L
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetazolamide Acetazolamide - analogs & derivatives Acetazolamide - pharmacology Animals Anticonvulsant activity Anticonvulsants - pharmacology Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Carbonic anhydrase inhibition Maximal electroshock test Medical sciences Mice Mice, Inbred BALB C Neuropharmacology Pharmacology. Drug treatments Sulfonamides Sulfonamides - chemistry Sulfonamides - pharmacology Thiadiazoles - chemistry Thiadiazoles - pharmacology
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Beschreibung
Zusammenfassung:	The anticonvulsant activity of 5-tertbutyloxycarbonylamido-1,3,4-thiadiazole-2-sulfonamide (BH 2ats) and 5-amino-1,3,4-thiadiazole-2-sulfonamide (Hats) was compared in mice, to that of acetazolamide (H 2acm). These compounds exhibit potent anticonvulsant activity and low minimal motor impairment.
ISSN:	0014-827X 1879-0569
DOI:	10.1016/S0014-827X(99)00096-8