Antidepressant effect and changes of GABAA receptor gamma2 subunit mRNA after hippocampal administration of allopregnanolone in rats

The present study aimed to verify the effect of bilateral intra-hippocampus administration of the neurosteroid allopregnanolone (3alpha-hydroxy-5alpha-pregnan-20-one; 3alpha, 5alpha-THP) in the forced swimming test (FST) and in the alpha4 and gamma2 GABA(A) receptor subunits gene expression. Results...

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Veröffentlicht in:	Journal of psychopharmacology (Oxford) 2008-07, Vol.22 (5), p.477-485
Hauptverfasser:	Nin, M S, Salles, F B, Azeredo, L A, Frazon, A P G, Gomez, R, Barros, H M T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antidepressive Agents - administration & dosage Antidepressive Agents - pharmacology Behavior, Animal - drug effects Disease Models, Animal Dose-Response Relationship, Drug Gene Expression Regulation - drug effects Hippocampus - metabolism Male Pregnanolone - administration & dosage Pregnanolone - pharmacology Rats Rats, Wistar Receptors, GABA-A - drug effects Receptors, GABA-A - metabolism RNA, Messenger - drug effects RNA, Messenger - metabolism Swimming
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Zusammenfassung:	The present study aimed to verify the effect of bilateral intra-hippocampus administration of the neurosteroid allopregnanolone (3alpha-hydroxy-5alpha-pregnan-20-one; 3alpha, 5alpha-THP) in the forced swimming test (FST) and in the alpha4 and gamma2 GABA(A) receptor subunits gene expression. Results showed that bilateral intra-hippocampal allopregnanolone administration of 2.5 microg/rat ( P
ISSN:	0269-8811
DOI:	10.1177/0269881107081525