Conjugation of Spermine Facilitates Cellular Uptake and Enhances Antitumor and Antibiotic Properties of Highly Lipophilic Porphyrins
Photodynamic therapy: The application of porphyrins in photodynamic therapy has been limited by their low solubility and cellular uptake efficiency. The introduction of a charged polyamine moiety to the lipophilic porphyrin ring can enhance the amphiphilicity of a compound of this class and ultimate...
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| Veröffentlicht in: | ChemMedChem 2008-08, Vol.3 (8), p.1185-1188 |
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| creator | Hahn, Frank Schmitz, Katja Balaban, Teodor S. Bräse, Stefan Schepers, Ute |
| description | Photodynamic therapy: The application of porphyrins in photodynamic therapy has been limited by their low solubility and cellular uptake efficiency. The introduction of a charged polyamine moiety to the lipophilic porphyrin ring can enhance the amphiphilicity of a compound of this class and ultimately lead to greater therapeutic efficacy. |
| doi_str_mv | 10.1002/cmdc.200800013 |
| format | Article |
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| ispartof | ChemMedChem, 2008-08, Vol.3 (8), p.1185-1188 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | amphiphilic porphyrins Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - metabolism Anti-Bacterial Agents - pharmacology antibiotics Antineoplastic Agents - chemistry Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Cell Survival - drug effects Cells, Cultured Humans Hydrophobic and Hydrophilic Interactions Lipids - chemistry Molecular Structure molecular transporters PDT polyamines Porphyrins - chemistry Porphyrins - metabolism Porphyrins - pharmacology solid-phase synthesis Spermine - chemistry Spermine - metabolism |
| title | Conjugation of Spermine Facilitates Cellular Uptake and Enhances Antitumor and Antibiotic Properties of Highly Lipophilic Porphyrins |
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