Conjugation of Spermine Facilitates Cellular Uptake and Enhances Antitumor and Antibiotic Properties of Highly Lipophilic Porphyrins

Photodynamic therapy: The application of porphyrins in photodynamic therapy has been limited by their low solubility and cellular uptake efficiency. The introduction of a charged polyamine moiety to the lipophilic porphyrin ring can enhance the amphiphilicity of a compound of this class and ultimate...

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Veröffentlicht in:	ChemMedChem 2008-08, Vol.3 (8), p.1185-1188
Hauptverfasser:	Hahn, Frank, Schmitz, Katja, Balaban, Teodor S., Bräse, Stefan, Schepers, Ute
Format:	Artikel
Sprache:	eng
Schlagworte:	amphiphilic porphyrins Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - metabolism Anti-Bacterial Agents - pharmacology antibiotics Antineoplastic Agents - chemistry Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Cell Survival - drug effects Cells, Cultured Humans Hydrophobic and Hydrophilic Interactions Lipids - chemistry Molecular Structure molecular transporters PDT polyamines Porphyrins - chemistry Porphyrins - metabolism Porphyrins - pharmacology solid-phase synthesis Spermine - chemistry Spermine - metabolism
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Beschreibung
Zusammenfassung:	Photodynamic therapy: The application of porphyrins in photodynamic therapy has been limited by their low solubility and cellular uptake efficiency. The introduction of a charged polyamine moiety to the lipophilic porphyrin ring can enhance the amphiphilicity of a compound of this class and ultimately lead to greater therapeutic efficacy.
ISSN:	1860-7179 1860-7187
DOI:	10.1002/cmdc.200800013