Glutamic acid decarboxylase mRNA in the suprachiasmatic nucleus of rats housed in constant darkness

This study demonstrates that the levels of the mRNAs encoding the two isoforms of glutamic acid decarboxylase (GAD) (i.e., GAD 65 and GAD 67) do not differ over the circadian activity cycle in the suprachiasmatic nucleus (SCN) of rats housed in constant darkness. These data indicate that the rhythmi...

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Veröffentlicht in:	Brain research 1999-12, Vol.851 (1), p.266-269
Hauptverfasser:	Huhman, Kim L, Jasnow, Aaron M, Sisitsky, Alison K, Albers, H.Elliott
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Circadian Circadian Rhythm - physiology Darkness Fundamental and applied biological sciences. Psychology GABA GAD 65 GAD 67 Glutamate Decarboxylase - metabolism In situ hybridization Male Rat Rats RNA, Messenger - metabolism SCN Suprachiasmatic Nucleus - metabolism Vertebrates: nervous system and sense organs
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Beschreibung
Zusammenfassung:	This study demonstrates that the levels of the mRNAs encoding the two isoforms of glutamic acid decarboxylase (GAD) (i.e., GAD 65 and GAD 67) do not differ over the circadian activity cycle in the suprachiasmatic nucleus (SCN) of rats housed in constant darkness. These data indicate that the rhythmic expression of GAD 65 mRNA previously observed in animals housed in a light:dark cycle [K.L. Huhman, A.C. Hennessey, H.E. Albers, Rhythms of glutamic acid decarboxylase mRNA in the suprachiasmatic nucleus, J. Biol. Rhythms 11 (1996) 311–316.] is the result of the activity of retinal afferents.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/S0006-8993(99)02167-8