Otx2's Incredible Journey

Otx2's Incredible Journey

A surprising new mechanism that regulates the plasticity of postnatal neurons is reported in this issue by Sugiyama et al. (2008). These authors show in mice that visual experience triggers cell-to-cell transfer of the homeoprotein Otx2 to cortical interneurons, where it promotes maturation of inhib...

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Veröffentlicht in:Cell 2008-08, Vol.134 (3), p.386-387
Hauptverfasser: Rebsam, Alexandra, Mason, Carol A.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Humans
Interneurons - physiology
Mice
Neuronal Plasticity
Otx Transcription Factors - metabolism
Sensory Deprivation
Visual Cortex - physiology
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Zusammenfassung:A surprising new mechanism that regulates the plasticity of postnatal neurons is reported in this issue by Sugiyama et al. (2008). These authors show in mice that visual experience triggers cell-to-cell transfer of the homeoprotein Otx2 to cortical interneurons, where it promotes maturation of inhibitory neural circuitry and opens the critical period for plasticity in the visual cortex.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2008.07.029