Efficient parallel synthesis of macrocyclic peptidomimetics

A new method for solid phase parallel synthesis of chemically and conformationally diverse macrocyclic peptidomimetics is reported. A new method for solid phase parallel synthesis of chemically and conformationally diverse macrocyclic peptidomimetics is reported. A key feature of the method is acces...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2008-08, Vol.18 (16), p.4731-4735
Hauptverfasser:	Marsault, Eric, Hoveyda, Hamid R., Gagnon, René, Peterson, Mark L., Vézina, Martin, Saint-Louis, Carl, Landry, Annick, Pinault, Jean-François, Ouellet, Luc, Beauchemin, Sophie, Beaubien, Sylvie, Mathieu, Axel, Benakli, Kamel, Wang, Zhigang, Brassard, Martin, Lonergan, David, Bilodeau, François, Ramaseshan, Mahesh, Fortin, Nadia, Lan, Ruoxi, Li, Shigui, Galaud, Fabrice, Plourde, Véronique, Champagne, Manon, Doucet, Annie, Bhérer, Patrick, Gauthier, Maude, Olsen, Gilles, Villeneuve, Gérald, Bhat, Shridhar, Foucher, Laurence, Fortin, Daniel, Peng, Xiaowen, Bernard, Sylvain, Drouin, Alexandre, Déziel, Robert, Berthiaume, Gilles, Dory, Yves L., Fraser, Graeme L., Deslongchamps, Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Chemistry Chemistry, Pharmaceutical - methods Combinatorial Chemistry Techniques Dimerization Dipeptides Exact sciences and technology Macrocycle Medical sciences Miscellaneous Models, Chemical Models, Molecular Molecular Conformation Molecular Mimicry Molecular Structure Organic chemistry Peptides Peptides - chemistry Peptides, Cyclic - chemistry Peptidomimetic Pharmacology. Drug treatments Preparations and properties Silver - chemistry Solid phase synthesis Stereoisomerism Structure-Activity Relationship Tether
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Beschreibung
Zusammenfassung:	A new method for solid phase parallel synthesis of chemically and conformationally diverse macrocyclic peptidomimetics is reported. A new method for solid phase parallel synthesis of chemically and conformationally diverse macrocyclic peptidomimetics is reported. A key feature of the method is access to broad chemical and conformational diversity. Synthesis and mechanistic studies on the macrocyclization step are reported.
ISSN:	0960-894X 0968-0896 1464-3405 1464-3391
DOI:	10.1016/j.bmcl.2008.06.085