Copper-Mediated C−H Bond Arylation of Arenes with Arylboronic Acids

A new copper-mediated cross-coupling of arenes and arylboronic acids is described. Under the influence of Cu(OCOCF3)2, the C−H bond arylation of electron-rich arenes with arylboronic acids takes place to afford a range of biaryls in good yields. The reaction is selective for cross-coupling; no homocoupling product arising from arenes or arylboronic acids is detected. Multiple C−H bond arylation is possible with indoles and pyrroles furnishing interesting extended π-systems.