Bioactive indole alkaloids from the bark of Uncaria guianensis

Abstract Bioassay-guided fractionation of the EtOH extract of the bark of UNCARIA GUIANENSIS (Aubl.) Cmel (Rubiaceae) using a yeast-based assay for DNA-damaging agents has furnished the two weakly but selectively active indole alkaloids uncarine C (1) and uncarine E (2) as the major bioactive consti...

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Veröffentlicht in:	Planta medica 1999-12, Vol.65 (8), p.759-760
Hauptverfasser:	Lee, K.K, Zhou, B.N, Kingston, D.G.I, Vaisberg, A.J, Hammond, G.B
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Alkaloids - chemistry Alkaloids - isolation & purification Alkaloids - pharmacology Animals bark bioassays Biological and medical sciences chemical constituents of plants chemical structure cytotoxicity dna modification dosage enzyme inhibitors fractionation General pharmacology Humans indole alkaloids Indoles - chemistry Letters Magnetic Resonance Spectroscopy Medical sciences Mice Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments plant extracts Rubiaceae - chemistry Tumor Cells, Cultured Uncaria
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Zusammenfassung:	Abstract Bioassay-guided fractionation of the EtOH extract of the bark of UNCARIA GUIANENSIS (Aubl.) Cmel (Rubiaceae) using a yeast-based assay for DNA-damaging agents has furnished the two weakly but selectively active indole alkaloids uncarine C (1) and uncarine E (2) as the major bioactive constituents in this assay.
ISSN:	0032-0943 1439-0221
DOI:	10.1055/s-2006-960860