Association between apolipoprotein E polymorphism and Alzheimer's disease in Koreans
We analyzed the aplolipoprotein E (APOE) genotypes of 110 probable AD patients and 226 cognitively normal controls in Koreans. The APOE ε4 allele was more prevalent in both early- and late-onset AD patients (P
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| Veröffentlicht in: | Neuroscience letters 1999-12, Vol.277 (3), p.145-148 |
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| container_title | Neuroscience letters |
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| creator | Kim, Ki Woong Jhoo, Jin Hyeong Lee, Kang Uk Lee, Dong Young Lee, Jung Hie Youn, Ji Youn Lee, Byeong Jae Han, Sul Hee Woo, Jong Inn |
| description | We analyzed the aplolipoprotein E (APOE) genotypes of 110 probable AD patients and 226 cognitively normal controls in Koreans. The APOE ε4 allele was more prevalent in both early- and late-onset AD patients (P |
| doi_str_mv | 10.1016/S0304-3940(99)00867-8 |
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P=0.02). In conclusion, the APOE ε4 allele increased the risk for AD in dose-dependent manner, and the APOE ε4-conferred AD risk was age- and sex-dependent in Koreans.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/S0304-3940(99)00867-8</identifier><identifier>PMID: 10626834</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Age ; Age of Onset ; Age-at-onset ; Aged ; Aged, 80 and over ; Alzheimer Disease - epidemiology ; Alzheimer Disease - genetics ; Alzheimer's disease ; Apolipoprotein E ; Apolipoprotein E4 ; Apolipoproteins E - genetics ; Asian Continental Ancestry Group - genetics ; Biological and medical sciences ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Female ; Gene Frequency ; Genotype ; Heterozygote ; Homozygote ; Humans ; Korea - ethnology ; Koreans ; Male ; Medical sciences ; Middle Aged ; Neurology ; Polymorphism, Genetic - physiology ; Reference Values ; Risk ; Sex ; Sex Characteristics</subject><ispartof>Neuroscience letters, 1999-12, Vol.277 (3), p.145-148</ispartof><rights>1999 Elsevier Science Ireland Ltd</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-1164ac14932066177e44b7dcb1f08a621a12bbba1c79f132df431f5f31694ad3</citedby><cites>FETCH-LOGICAL-c421t-1164ac14932066177e44b7dcb1f08a621a12bbba1c79f132df431f5f31694ad3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0304-3940(99)00867-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1208787$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10626834$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Ki Woong</creatorcontrib><creatorcontrib>Jhoo, Jin Hyeong</creatorcontrib><creatorcontrib>Lee, Kang Uk</creatorcontrib><creatorcontrib>Lee, Dong Young</creatorcontrib><creatorcontrib>Lee, Jung Hie</creatorcontrib><creatorcontrib>Youn, Ji Youn</creatorcontrib><creatorcontrib>Lee, Byeong Jae</creatorcontrib><creatorcontrib>Han, Sul Hee</creatorcontrib><creatorcontrib>Woo, Jong Inn</creatorcontrib><title>Association between apolipoprotein E polymorphism and Alzheimer's disease in Koreans</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>We analyzed the aplolipoprotein E (APOE) genotypes of 110 probable AD patients and 226 cognitively normal controls in Koreans. The APOE ε4 allele was more prevalent in both early- and late-onset AD patients (P<0.01) than in controls. The odds for the APOE ε4-heterozygous subjects were 2.7 (95% CI=1.6–4.5), and those for the APOE ε4-homozygous subjects were 17.4 (95% CI=2.0–147.3). But the odds were not uniform across age groups, and were higher in women than in men. Although the APOE ε2 allele frequency did not differ by diagnosis, the patients carrying an APOE ε2 allele showed delayed age-at-onset (
P=0.02). In conclusion, the APOE ε4 allele increased the risk for AD in dose-dependent manner, and the APOE ε4-conferred AD risk was age- and sex-dependent in Koreans.</description><subject>Age</subject><subject>Age of Onset</subject><subject>Age-at-onset</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - epidemiology</subject><subject>Alzheimer Disease - genetics</subject><subject>Alzheimer's disease</subject><subject>Apolipoprotein E</subject><subject>Apolipoprotein E4</subject><subject>Apolipoproteins E - genetics</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Biological and medical sciences</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genotype</subject><subject>Heterozygote</subject><subject>Homozygote</subject><subject>Humans</subject><subject>Korea - ethnology</subject><subject>Koreans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Polymorphism, Genetic - physiology</subject><subject>Reference Values</subject><subject>Risk</subject><subject>Sex</subject><subject>Sex Characteristics</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0E1P3DAQgGELgWCh_QmgHFAph7Qe22vHJ7RC9ENF6qF7txxnIlwlcfBkqeivJ7Ar2hsny9Iz9uhl7BT4J-CgP__ikqtSWsU_WnvJeaVNWe2xBVRGlMYasc8Wr-SIHRP95pwvYakO2RFwLXQl1YKtV0QpRD_FNBQ1Tn8Qh8KPqYtjGnOaMA7FTTHfH_uUx7tIfeGHplh1f-8w9pgvqGgioScsZvkjZfQDvWMHre8I3-_OE7b-crO-_lbe_vz6_Xp1WwYlYCoBtPIBlJWCaw3GoFK1aUINLa-8FuBB1HXtIRjbghRNqyS0y1aCtso38oR92D47L3q_QZpcHylg1_kB04acttKCAv0mBKOMkAZmuNzCkBNRxtaNOfY-Pzrg7jm7e8nunps6a91LdlfNc2e7DzZ1j81_U9vOMzjfAU_Bd232Q4j0zwlemcrM7GrLcK72EDE7ChGHgE3MGCbXpPjGJk86hJ6P</recordid><startdate>19991231</startdate><enddate>19991231</enddate><creator>Kim, Ki Woong</creator><creator>Jhoo, Jin Hyeong</creator><creator>Lee, Kang Uk</creator><creator>Lee, Dong Young</creator><creator>Lee, Jung Hie</creator><creator>Youn, Ji Youn</creator><creator>Lee, Byeong Jae</creator><creator>Han, Sul Hee</creator><creator>Woo, Jong Inn</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19991231</creationdate><title>Association between apolipoprotein E polymorphism and Alzheimer's disease in Koreans</title><author>Kim, Ki Woong ; Jhoo, Jin Hyeong ; Lee, Kang Uk ; Lee, Dong Young ; Lee, Jung Hie ; Youn, Ji Youn ; Lee, Byeong Jae ; Han, Sul Hee ; Woo, Jong Inn</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-1164ac14932066177e44b7dcb1f08a621a12bbba1c79f132df431f5f31694ad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Age</topic><topic>Age of Onset</topic><topic>Age-at-onset</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - epidemiology</topic><topic>Alzheimer Disease - genetics</topic><topic>Alzheimer's disease</topic><topic>Apolipoprotein E</topic><topic>Apolipoprotein E4</topic><topic>Apolipoproteins E - genetics</topic><topic>Asian Continental Ancestry Group - genetics</topic><topic>Biological and medical sciences</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genotype</topic><topic>Heterozygote</topic><topic>Homozygote</topic><topic>Humans</topic><topic>Korea - ethnology</topic><topic>Koreans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Polymorphism, Genetic - physiology</topic><topic>Reference Values</topic><topic>Risk</topic><topic>Sex</topic><topic>Sex Characteristics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Ki Woong</creatorcontrib><creatorcontrib>Jhoo, Jin Hyeong</creatorcontrib><creatorcontrib>Lee, Kang Uk</creatorcontrib><creatorcontrib>Lee, Dong Young</creatorcontrib><creatorcontrib>Lee, Jung Hie</creatorcontrib><creatorcontrib>Youn, Ji Youn</creatorcontrib><creatorcontrib>Lee, Byeong Jae</creatorcontrib><creatorcontrib>Han, Sul Hee</creatorcontrib><creatorcontrib>Woo, Jong Inn</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Ki Woong</au><au>Jhoo, Jin Hyeong</au><au>Lee, Kang Uk</au><au>Lee, Dong Young</au><au>Lee, Jung Hie</au><au>Youn, Ji Youn</au><au>Lee, Byeong Jae</au><au>Han, Sul Hee</au><au>Woo, Jong Inn</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between apolipoprotein E polymorphism and Alzheimer's disease in Koreans</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>1999-12-31</date><risdate>1999</risdate><volume>277</volume><issue>3</issue><spage>145</spage><epage>148</epage><pages>145-148</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>We analyzed the aplolipoprotein E (APOE) genotypes of 110 probable AD patients and 226 cognitively normal controls in Koreans. The APOE ε4 allele was more prevalent in both early- and late-onset AD patients (P<0.01) than in controls. The odds for the APOE ε4-heterozygous subjects were 2.7 (95% CI=1.6–4.5), and those for the APOE ε4-homozygous subjects were 17.4 (95% CI=2.0–147.3). But the odds were not uniform across age groups, and were higher in women than in men. Although the APOE ε2 allele frequency did not differ by diagnosis, the patients carrying an APOE ε2 allele showed delayed age-at-onset (
P=0.02). In conclusion, the APOE ε4 allele increased the risk for AD in dose-dependent manner, and the APOE ε4-conferred AD risk was age- and sex-dependent in Koreans.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>10626834</pmid><doi>10.1016/S0304-3940(99)00867-8</doi><tpages>4</tpages></addata></record> |
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| ispartof | Neuroscience letters, 1999-12, Vol.277 (3), p.145-148 |
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| subjects | Age Age of Onset Age-at-onset Aged Aged, 80 and over Alzheimer Disease - epidemiology Alzheimer Disease - genetics Alzheimer's disease Apolipoprotein E Apolipoprotein E4 Apolipoproteins E - genetics Asian Continental Ancestry Group - genetics Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Gene Frequency Genotype Heterozygote Homozygote Humans Korea - ethnology Koreans Male Medical sciences Middle Aged Neurology Polymorphism, Genetic - physiology Reference Values Risk Sex Sex Characteristics |
| title | Association between apolipoprotein E polymorphism and Alzheimer's disease in Koreans |
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