Effect of i.v. furosemide on pelvic urinary oxygen tension in humans

Urinary oxygen tension may be an index of renal medullary blood flow. The effect of i.v. furosemide on urinary oxygen tension was studied in four patients with indwelling nephrostomy tubes. An intravascular oxygen sensor (Paratrend 7, Biomedical Sensors Ltd, UK) was inserted into the renal pelvis vi...

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Veröffentlicht in:	British journal of anaesthesia : BJA 1999-08, Vol.83 (2), p.328-329
Hauptverfasser:	Tolley, P M, Purcell, A, Bolsin, S N
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Biomarkers - urine Diuretics - pharmacology Furosemide - pharmacology Humans Injections, Intravenous Kidney Medulla - blood supply Medical sciences Oxygen - urine Pharmacology. Drug treatments Regional Blood Flow - drug effects Urinary system
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Zusammenfassung:	Urinary oxygen tension may be an index of renal medullary blood flow. The effect of i.v. furosemide on urinary oxygen tension was studied in four patients with indwelling nephrostomy tubes. An intravascular oxygen sensor (Paratrend 7, Biomedical Sensors Ltd, UK) was inserted into the renal pelvis via the nephrostomy and urine oxygen tension measured. In all cases, furosemide 20 mg i.v. produced a decrease in pelvic urinary oxygen. The possible mechanisms and implications are discussed.
ISSN:	0007-0912 1471-6771
DOI:	10.1093/bja/83.2.328