Acylated pregnane glycosides from Caralluma tuberculata and their antiparasitic activity

Six pregnane glycosides were isolated from Caralluma tuberculata, including five ones (1–5). The structures of the isolated compounds were elucidated by the analysis of NMR data and FAB–MS experiments. All the isolated compounds were tested for their antimalarial and antitrypanosomal activities as w...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Phytochemistry (Oxford) 2008-08, Vol.69 (11), p.2180-2186
Hauptverfasser:	Abdel-Sattar, Essam, Harraz, Fathalla M., Al-ansari, Soliman Mohammed Abdullah, El-Mekkawy, Sahar, Ichino, Chikara, Kiyohara, Hiroaki, Ishiyama, Aki, Otoguro, Kazuhiko, Omura, Satoshi, Yamada, Haruki
Format:	Artikel
Sprache:	eng
Schlagworte:	Acylation Animals Antimalarial activity Antiparasitic Agents - chemistry Antiparasitic Agents - pharmacology antiprotozoal properties Antitrypanosomal activity Apocynaceae - chemistry Asclepiadaceae Biological and medical sciences Caralluma Caralluma tuberculata caratuberside Chemical constitution chemical structure cultured cells Cytotoxicity Fundamental and applied biological sciences. Psychology General pharmacology glycosides Glycosides - chemistry Glycosides - pharmacology humans Magnetic Resonance Spectroscopy Medical sciences Molecular Structure Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant physiology and development Plasmodium falciparum Plasmodium falciparum - drug effects pregnane Pregnane glycosides Pregnanes - chemistry spectral analysis steroids Structure-Activity Relationship Trypanosoma brucei brucei
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Six pregnane glycosides were isolated from Caralluma tuberculata, including five ones (1–5). The structures of the isolated compounds were elucidated by the analysis of NMR data and FAB–MS experiments. All the isolated compounds were tested for their antimalarial and antitrypanosomal activities as well as their cytotoxicity against human diploid embryonic cell line (MRC-5). Five pregnane glycosides were isolated from Caralluma tuberculata (1–5), in addition to a known one (russelioside E, 6). The structures of the isolated compounds were elucidated by the analysis of NMR data and FAB–MS experiments. All the isolated compounds were tested for their antimalarial and antitrypanosomal activities as well as their cytotoxicity against human diploid embryonic cell line (MRC5).
ISSN:	0031-9422 1873-3700
DOI:	10.1016/j.phytochem.2008.05.017