Mouse but not human embryonic stem cells are deficient in rejoining of ionizing radiation-induced DNA double-strand breaks

Mouse embryonic stem (mES) cells will give rise to all of the cells of the adult mouse, but they failed to rejoin half of the DNA double-strand breaks (dsb) produced by high doses of ionizing radiation. A deficiency in DNA-PK cs appears to be responsible since mES cells expressed

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Bibliographische Detailangaben
Veröffentlicht in:	DNA repair 2008-09, Vol.7 (9), p.1471-1483
Hauptverfasser:	Bañuelos, C.A., Banáth, J.P., MacPhail, S.H., Zhao, J., Eaves, C.A., O’Connor, M.D., Lansdorp, P.M., Olive, P.L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Nuclear - metabolism Ataxia Telangiectasia Mutated Proteins Bacteriology Biological and medical sciences Calcium-Binding Proteins - metabolism Cell Cycle Proteins - metabolism Cell Line DNA Breaks, Double-Stranded - radiation effects DNA Repair DNA-Activated Protein Kinase - antagonists & inhibitors DNA-Activated Protein Kinase - metabolism DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - metabolism DNA-PK Double-strand break repair Embryonic Stem Cells - radiation effects Fundamental and applied biological sciences. Psychology G1 Phase Growth, nutrition, cell differenciation Histones - genetics Histones - metabolism Humans Ku Autoantigen Mice Microbiology Molecular and cellular biology Molecular genetics Mouse embryonic stem cells Mutagenesis. Repair Nuclear Proteins - antagonists & inhibitors Nuclear Proteins - metabolism Protein-Serine-Threonine Kinases - metabolism Radiation, Ionizing Tumor Suppressor Proteins - metabolism γH2AX
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Beschreibung
Zusammenfassung:	Mouse embryonic stem (mES) cells will give rise to all of the cells of the adult mouse, but they failed to rejoin half of the DNA double-strand breaks (dsb) produced by high doses of ionizing radiation. A deficiency in DNA-PK cs appears to be responsible since mES cells expressed
ISSN:	1568-7864 1568-7856
DOI:	10.1016/j.dnarep.2008.05.005