Cyanopeptoline CB071: A Cyclic Depsipeptide Isolated from the Freshwater Cyanobacterium Aphanocapsa sp
Cyanopeptolin CB071 (1), a trypsin inhibitor, was isolated from the freshwater cyanobacterium Aphanocapsa sp. Its complete structure was determined by detailed NMR spectroscopy and MS analyses, along with chemical reactions. The compound showed inhibition of trypsin at a concentration of IC50=2.5 μM...
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 2008/08/01, Vol.56(8), pp.1191-1193 |
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| container_title | Chemical & pharmaceutical bulletin |
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| creator | Choi, Hyukjae Oh, Sun Kwan Yih, Wonho Chin, Jungwook Kang, Heonjoong Rho, Jung-Rae |
| description | Cyanopeptolin CB071 (1), a trypsin inhibitor, was isolated from the freshwater cyanobacterium Aphanocapsa sp. Its complete structure was determined by detailed NMR spectroscopy and MS analyses, along with chemical reactions. The compound showed inhibition of trypsin at a concentration of IC50=2.5 μM. |
| doi_str_mv | 10.1248/cpb.56.1191 |
| format | Article |
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Its complete structure was determined by detailed NMR spectroscopy and MS analyses, along with chemical reactions. The compound showed inhibition of trypsin at a concentration of IC50=2.5 μM.</description><identifier>ISSN: 0009-2363</identifier><identifier>EISSN: 1347-5223</identifier><identifier>DOI: 10.1248/cpb.56.1191</identifier><identifier>PMID: 18670126</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>2D NMR ; Aphanocapsa ; Aphanocapsa sp ; Cyanobacteria - chemistry ; cyanopeptolin CB071 ; Cyanophyta ; Depsipeptides - chemistry ; Depsipeptides - isolation & purification ; Depsipeptides - pharmacology ; Fresh Water - microbiology ; Molecular Structure ; trypsin inhibitor ; Trypsin Inhibitors - chemistry ; Trypsin Inhibitors - isolation & purification ; Trypsin Inhibitors - pharmacology</subject><ispartof>Chemical and Pharmaceutical Bulletin, 2008/08/01, Vol.56(8), pp.1191-1193</ispartof><rights>2008 The Pharmaceutical Society of Japan</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c469t-198ad0d43c1ebcb01e77924e53784147c78b6cd0cf75798249599edfc21c1acf3</citedby><cites>FETCH-LOGICAL-c469t-198ad0d43c1ebcb01e77924e53784147c78b6cd0cf75798249599edfc21c1acf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1876,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18670126$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Choi, Hyukjae</creatorcontrib><creatorcontrib>Oh, Sun Kwan</creatorcontrib><creatorcontrib>Yih, Wonho</creatorcontrib><creatorcontrib>Chin, Jungwook</creatorcontrib><creatorcontrib>Kang, Heonjoong</creatorcontrib><creatorcontrib>Rho, Jung-Rae</creatorcontrib><title>Cyanopeptoline CB071: A Cyclic Depsipeptide Isolated from the Freshwater Cyanobacterium Aphanocapsa sp</title><title>Chemical & pharmaceutical bulletin</title><addtitle>Chem. Pharm. Bull.</addtitle><description>Cyanopeptolin CB071 (1), a trypsin inhibitor, was isolated from the freshwater cyanobacterium Aphanocapsa sp. Its complete structure was determined by detailed NMR spectroscopy and MS analyses, along with chemical reactions. 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Oh, Sun Kwan ; Yih, Wonho ; Chin, Jungwook ; Kang, Heonjoong ; Rho, Jung-Rae</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c469t-198ad0d43c1ebcb01e77924e53784147c78b6cd0cf75798249599edfc21c1acf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>2D NMR</topic><topic>Aphanocapsa</topic><topic>Aphanocapsa sp</topic><topic>Cyanobacteria - chemistry</topic><topic>cyanopeptolin CB071</topic><topic>Cyanophyta</topic><topic>Depsipeptides - chemistry</topic><topic>Depsipeptides - isolation & purification</topic><topic>Depsipeptides - pharmacology</topic><topic>Fresh Water - microbiology</topic><topic>Molecular Structure</topic><topic>trypsin inhibitor</topic><topic>Trypsin Inhibitors - chemistry</topic><topic>Trypsin Inhibitors - isolation & purification</topic><topic>Trypsin Inhibitors - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Choi, Hyukjae</creatorcontrib><creatorcontrib>Oh, Sun Kwan</creatorcontrib><creatorcontrib>Yih, Wonho</creatorcontrib><creatorcontrib>Chin, Jungwook</creatorcontrib><creatorcontrib>Kang, Heonjoong</creatorcontrib><creatorcontrib>Rho, Jung-Rae</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>ASFA: Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Choi, Hyukjae</au><au>Oh, Sun Kwan</au><au>Yih, Wonho</au><au>Chin, Jungwook</au><au>Kang, Heonjoong</au><au>Rho, Jung-Rae</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cyanopeptoline CB071: A Cyclic Depsipeptide Isolated from the Freshwater Cyanobacterium Aphanocapsa sp</atitle><jtitle>Chemical & pharmaceutical bulletin</jtitle><addtitle>Chem. Pharm. Bull.</addtitle><date>2008-08-01</date><risdate>2008</risdate><volume>56</volume><issue>8</issue><spage>1191</spage><epage>1193</epage><pages>1191-1193</pages><issn>0009-2363</issn><eissn>1347-5223</eissn><abstract>Cyanopeptolin CB071 (1), a trypsin inhibitor, was isolated from the freshwater cyanobacterium Aphanocapsa sp. Its complete structure was determined by detailed NMR spectroscopy and MS analyses, along with chemical reactions. The compound showed inhibition of trypsin at a concentration of IC50=2.5 μM.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>18670126</pmid><doi>10.1248/cpb.56.1191</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | 2D NMR Aphanocapsa Aphanocapsa sp Cyanobacteria - chemistry cyanopeptolin CB071 Cyanophyta Depsipeptides - chemistry Depsipeptides - isolation & purification Depsipeptides - pharmacology Fresh Water - microbiology Molecular Structure trypsin inhibitor Trypsin Inhibitors - chemistry Trypsin Inhibitors - isolation & purification Trypsin Inhibitors - pharmacology |
| title | Cyanopeptoline CB071: A Cyclic Depsipeptide Isolated from the Freshwater Cyanobacterium Aphanocapsa sp |
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