Cyanopeptoline CB071: A Cyclic Depsipeptide Isolated from the Freshwater Cyanobacterium Aphanocapsa sp

Cyanopeptolin CB071 (1), a trypsin inhibitor, was isolated from the freshwater cyanobacterium Aphanocapsa sp. Its complete structure was determined by detailed NMR spectroscopy and MS analyses, along with chemical reactions. The compound showed inhibition of trypsin at a concentration of IC50=2.5 μM...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2008/08/01, Vol.56(8), pp.1191-1193
Hauptverfasser:	Choi, Hyukjae, Oh, Sun Kwan, Yih, Wonho, Chin, Jungwook, Kang, Heonjoong, Rho, Jung-Rae
Format:	Artikel
Sprache:	eng
Schlagworte:	2D NMR Aphanocapsa Aphanocapsa sp Cyanobacteria - chemistry cyanopeptolin CB071 Cyanophyta Depsipeptides - chemistry Depsipeptides - isolation & purification Depsipeptides - pharmacology Fresh Water - microbiology Molecular Structure trypsin inhibitor Trypsin Inhibitors - chemistry Trypsin Inhibitors - isolation & purification Trypsin Inhibitors - pharmacology
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Beschreibung
Zusammenfassung:	Cyanopeptolin CB071 (1), a trypsin inhibitor, was isolated from the freshwater cyanobacterium Aphanocapsa sp. Its complete structure was determined by detailed NMR spectroscopy and MS analyses, along with chemical reactions. The compound showed inhibition of trypsin at a concentration of IC50=2.5 μM.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.56.1191