Bone marrow cell trafficking following intravenous administration

To address trafficking of transplanted marrow cells immediately after intravenous infusion, we examined the early fate of infused non‐adherent, low‐density donor bone marrow cells in a syngeneic mouse model. The presence of infused donor cells, marked with indium‐111 oxine (111In), with the fluoresc...

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Veröffentlicht in:	British journal of haematology 1999-12, Vol.107 (4), p.895-902
Hauptverfasser:	Cui, Jisong, Wahl, Richard L., Shen, Tingliang, Fisher, Susan J., Recker, Elizabeth, Ginsburg, David, Long, Michael W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences bone marrow Bone Marrow Transplantation - physiology Bone marrow, stem cells transplantation. Graft versus host reaction cell migration Cell Movement - physiology Flow Cytometry haemopoiesis Hematology Hematopoiesis - physiology homing Infusions, Intravenous Medical sciences Mice Mice, Inbred BALB C Polymerase Chain Reaction - methods Transfusions. Complications. Transfusion reactions. Cell and gene therapy transplantation
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Zusammenfassung:	To address trafficking of transplanted marrow cells immediately after intravenous infusion, we examined the early fate of infused non‐adherent, low‐density donor bone marrow cells in a syngeneic mouse model. The presence of infused donor cells, marked with indium‐111 oxine (111In), with the fluorescent dye PKH26, or by a detectable transgene marker, was evaluated at 3–48 h in a variety of tissues, including peripheral blood. All three cell‐marking methods indicated a rapid (
ISSN:	0007-1048 1365-2141
DOI:	10.1046/j.1365-2141.1999.01779.x