Design and synthesis of regioisomerically pure unsymmetrical xanthene derivatives for staining live cells and their photochemical properties

We show here the synthesis of regioisomerically pure unsymmetrical xanthene derivatives by combining three units, just like pieces of a jigsaw puzzle. We have demonstrated the synthesis of regioisomerically pure unsymmetrical xanthene derivatives consisting of three units which can be independently...

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Veröffentlicht in:Bioorganic & medicinal chemistry 2008-08, Vol.18 (15), p.4380-4384
Hauptverfasser: Kamino, Shinichiro, Ichikawa, Hayato, Wada, Shun-ichi, Horio, Yuka, Usami, Yoshihide, Yamaguchi, Takako, Koda, Toshiki, Harada, Aki, Shimanuki, Kazusa, Arimoto, Masao, Doi, Mitsunobu, Fujita, Yoshikazu
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Sprache:eng
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Zusammenfassung:We show here the synthesis of regioisomerically pure unsymmetrical xanthene derivatives by combining three units, just like pieces of a jigsaw puzzle. We have demonstrated the synthesis of regioisomerically pure unsymmetrical xanthene derivatives consisting of three units which can be independently modified to control their physical properties. The photochemical properties of the synthetic unsymmetrical xanthene derivatives were investigated in solution by UV–vis absorption and fluorescence measurements, and their cell imaging properties were examined by confocal laser-scanning microscopy.
ISSN:0960-894X
0968-0896
1464-3405
1464-3391
DOI:10.1016/j.bmcl.2008.06.065