Dendritic cells produce interleukin-12 in hyperthyroid mice
We previously reported that serum interleukin-12 (IL-12) levels were significantly increased in patients with hyperthyroid Graves' disease and in normal subjects after administration of thyroid hormone. In the present study, we investigated which cells produce IL-12 and the interactions between...
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| Veröffentlicht in: | European journal of endocrinology 1999-12, Vol.141 (6), p.625-629 |
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| container_title | European journal of endocrinology |
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| creator | TAMARU, M MATSUURA, B MIYAUCHI, S ONJI, M |
| description | We previously reported that serum interleukin-12 (IL-12) levels were significantly increased in patients with hyperthyroid Graves' disease and in normal subjects after administration of thyroid hormone. In the present study, we investigated which cells produce IL-12 and the interactions between IL-12 and thyroid hormones, using a hyperthyroid mouse model. Thyroid hormones induced IL-12 production, and IL-12 was mainly produced by dendritic cells outside the thyroid glands in a hyperthyroid state. |
| doi_str_mv | 10.1530/eje.0.1410625 |
| format | Article |
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In the present study, we investigated which cells produce IL-12 and the interactions between IL-12 and thyroid hormones, using a hyperthyroid mouse model. Thyroid hormones induced IL-12 production, and IL-12 was mainly produced by dendritic cells outside the thyroid glands in a hyperthyroid state.</description><identifier>ISSN: 0804-4643</identifier><identifier>EISSN: 1479-683X</identifier><identifier>DOI: 10.1530/eje.0.1410625</identifier><identifier>PMID: 10601966</identifier><language>eng</language><publisher>Colchester: Portland Press</publisher><subject>Animals ; Biological and medical sciences ; Cells, Cultured ; Dendritic Cells - metabolism ; Endocrinopathies ; Hyperthyroidism - blood ; Hyperthyroidism - metabolism ; Interleukin-10 - biosynthesis ; Interleukin-10 - blood ; Interleukin-12 - biosynthesis ; Interleukin-12 - blood ; Male ; Medical sciences ; Mice ; Mice, Inbred C57BL ; Non tumoral diseases. Target tissue resistance. 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Benign neoplasms</subject><subject>Organ Size</subject><subject>Spleen - cytology</subject><subject>Thyroid. 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Target tissue resistance. Benign neoplasms</topic><topic>Organ Size</topic><topic>Spleen - cytology</topic><topic>Thyroid. 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| identifier | ISSN: 0804-4643 |
| ispartof | European journal of endocrinology, 1999-12, Vol.141 (6), p.625-629 |
| issn | 0804-4643 1479-683X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69358896 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE |
| subjects | Animals Biological and medical sciences Cells, Cultured Dendritic Cells - metabolism Endocrinopathies Hyperthyroidism - blood Hyperthyroidism - metabolism Interleukin-10 - biosynthesis Interleukin-10 - blood Interleukin-12 - biosynthesis Interleukin-12 - blood Male Medical sciences Mice Mice, Inbred C57BL Non tumoral diseases. Target tissue resistance. Benign neoplasms Organ Size Spleen - cytology Thyroid. Thyroid axis (diseases) |
| title | Dendritic cells produce interleukin-12 in hyperthyroid mice |
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