Dendritic cells produce interleukin-12 in hyperthyroid mice

Dendritic cells produce interleukin-12 in hyperthyroid mice

We previously reported that serum interleukin-12 (IL-12) levels were significantly increased in patients with hyperthyroid Graves' disease and in normal subjects after administration of thyroid hormone. In the present study, we investigated which cells produce IL-12 and the interactions between...

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Veröffentlicht in:European journal of endocrinology 1999-12, Vol.141 (6), p.625-629
Hauptverfasser: TAMARU, M, MATSUURA, B, MIYAUCHI, S, ONJI, M
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biological and medical sciences
Cells, Cultured
Dendritic Cells - metabolism
Endocrinopathies
Hyperthyroidism - blood
Hyperthyroidism - metabolism
Interleukin-10 - biosynthesis
Interleukin-10 - blood
Interleukin-12 - biosynthesis
Interleukin-12 - blood
Male
Medical sciences
Mice
Mice, Inbred C57BL
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Organ Size
Spleen - cytology
Thyroid. Thyroid axis (diseases)
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Zusammenfassung:We previously reported that serum interleukin-12 (IL-12) levels were significantly increased in patients with hyperthyroid Graves' disease and in normal subjects after administration of thyroid hormone. In the present study, we investigated which cells produce IL-12 and the interactions between IL-12 and thyroid hormones, using a hyperthyroid mouse model. Thyroid hormones induced IL-12 production, and IL-12 was mainly produced by dendritic cells outside the thyroid glands in a hyperthyroid state.
ISSN:0804-4643
1479-683X
DOI:10.1530/eje.0.1410625