Synthesis and anti-inflammatory activity of 2-(2-aroylaroxy)-4,6-dimethoxy pyrimidines

The newly synthesized compounds 2-(2-aroylaroxy)-4,6-dimethoxy pyrimidines 7a– f were screened for their anti-inflammatory activity and compared with standard drugs. Abstract-Reaction of 6a– f individually with 2-methylsulfonyl-4,6-dimethoxypyrimidine yielded 7a– f in excellent yield. The newly synt...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2008-08, Vol.18 (15), p.4409-4412
Hauptverfasser:	Venu, T.D., Khanum, S.A., Firdouse, Aiysha, Manuprasad, B.K., Shashikanth, Sheena, Mohamed, Riyaz, Vishwanth, Bannikuppe Sannanaik
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Animals Animals, Inbred Strains Anti-inflammatory activity Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - pharmacology Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Disease Models, Animal Edema - chemically induced Edema - drug therapy Edema - prevention & control Foot - pathology Medical sciences Mice Pharmacology. Drug treatments Phospholipases A2 - metabolism Prostaglandin-Endoperoxide Synthases - metabolism Pyrimidines Pyrimidines - chemical synthesis Pyrimidines - chemistry Pyrimidines - pharmacology Rats Synthesis Ulcer - etiology
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