Synthesis and anti-inflammatory activity of 2-(2-aroylaroxy)-4,6-dimethoxy pyrimidines

The newly synthesized compounds 2-(2-aroylaroxy)-4,6-dimethoxy pyrimidines 7a– f were screened for their anti-inflammatory activity and compared with standard drugs. Abstract-Reaction of 6a– f individually with 2-methylsulfonyl-4,6-dimethoxypyrimidine yielded 7a– f in excellent yield. The newly synthesized heterocycles were characterized by IR, 1H NMR, and mass spectral data. Compounds 7a– f was screened for their anti-inflammatory activity and were compared with standard drugs. Of the compounds studied, the compound 7e showed more potent activity than the standard drugs at all doses tested.