Synthesis and anti-inflammatory activity of 2-(2-aroylaroxy)-4,6-dimethoxy pyrimidines
The newly synthesized compounds 2-(2-aroylaroxy)-4,6-dimethoxy pyrimidines 7a– f were screened for their anti-inflammatory activity and compared with standard drugs. Abstract-Reaction of 6a– f individually with 2-methylsulfonyl-4,6-dimethoxypyrimidine yielded 7a– f in excellent yield. The newly synt...
Gespeichert in:
| Veröffentlicht in: | Bioorganic & medicinal chemistry 2008-08, Vol.18 (15), p.4409-4412 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 4412 |
|---|---|
| container_issue | 15 |
| container_start_page | 4409 |
| container_title | Bioorganic & medicinal chemistry |
| container_volume | 18 |
| creator | Venu, T.D. Khanum, S.A. Firdouse, Aiysha Manuprasad, B.K. Shashikanth, Sheena Mohamed, Riyaz Vishwanth, Bannikuppe Sannanaik |
| description | The newly synthesized compounds 2-(2-aroylaroxy)-4,6-dimethoxy pyrimidines
7a–
f were screened for their anti-inflammatory activity and compared with standard drugs.
Abstract-Reaction of
6a–
f individually with 2-methylsulfonyl-4,6-dimethoxypyrimidine yielded
7a–
f in excellent yield. The newly synthesized heterocycles were characterized by IR,
1H NMR, and mass spectral data. Compounds
7a–
f was screened for their anti-inflammatory activity and were compared with standard drugs. Of the compounds studied, the compound
7e showed more potent activity than the standard drugs at all doses tested. |
| doi_str_mv | 10.1016/j.bmcl.2008.06.061 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69358386</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0960894X08007105</els_id><sourcerecordid>19717498</sourcerecordid><originalsourceid>FETCH-LOGICAL-c415t-9a23faa5a3e8906e27afa2861079645b167c2cdd605ee71588b10ba7f3e4c7ba3</originalsourceid><addsrcrecordid>eNqFkE2LFDEQhoMo7rj6BzxIXxQFM1bSSTqBvcjiFyx48ANvoTpdzWbojzHpWex_b4YZ9KZQSRF46qXyMPZUwFaAMG9223YMw1YC2C2YUuIe2whlFK8V6PtsA84At079uGCPct4BCAVKPWQXwhoptNQb9v3LOi23lGOucOrKWSKPUz_gOOIyp7XCsMS7uKzV3FeSv5Qc07wO5fq1vuLqteFdHGm5Lc9qv6Y4xi5OlB-zBz0OmZ6c-yX79v7d1-uP_Obzh0_Xb294UEIv3KGse0SNNVkHhmSDPUprBDTOKN0K0wQZus6AJmqEtrYV0GLT16RC02J9yV6ccvdp_nmgvPgx5kDDgBPNh-yNq7WtrfkvKFwjGuVsAeUJDGnOOVHv9-VXmFYvwB-1-50_avdH7R5MKVGGnp3TD-1I3d-Rs-cCPD8DmAMOfcIpxPyHk6CtsE4W7urEUZF2Fyn5HCJNgbqYKCy-m-O_9vgN_32gag</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>19717498</pqid></control><display><type>article</type><title>Synthesis and anti-inflammatory activity of 2-(2-aroylaroxy)-4,6-dimethoxy pyrimidines</title><source>Elsevier ScienceDirect Journals Complete - AutoHoldings</source><source>MEDLINE</source><creator>Venu, T.D. ; Khanum, S.A. ; Firdouse, Aiysha ; Manuprasad, B.K. ; Shashikanth, Sheena ; Mohamed, Riyaz ; Vishwanth, Bannikuppe Sannanaik</creator><creatorcontrib>Venu, T.D. ; Khanum, S.A. ; Firdouse, Aiysha ; Manuprasad, B.K. ; Shashikanth, Sheena ; Mohamed, Riyaz ; Vishwanth, Bannikuppe Sannanaik</creatorcontrib><description>The newly synthesized compounds 2-(2-aroylaroxy)-4,6-dimethoxy pyrimidines
7a–
f were screened for their anti-inflammatory activity and compared with standard drugs.
Abstract-Reaction of
6a–
f individually with 2-methylsulfonyl-4,6-dimethoxypyrimidine yielded
7a–
f in excellent yield. The newly synthesized heterocycles were characterized by IR,
1H NMR, and mass spectral data. Compounds
7a–
f was screened for their anti-inflammatory activity and were compared with standard drugs. Of the compounds studied, the compound
7e showed more potent activity than the standard drugs at all doses tested.</description><identifier>ISSN: 0960-894X</identifier><identifier>ISSN: 0968-0896</identifier><identifier>EISSN: 1464-3405</identifier><identifier>EISSN: 1464-3391</identifier><identifier>DOI: 10.1016/j.bmcl.2008.06.061</identifier><identifier>PMID: 18621525</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Algorithms ; Animals ; Animals, Inbred Strains ; Anti-inflammatory activity ; Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis ; Anti-Inflammatory Agents, Non-Steroidal - chemistry ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; Biological and medical sciences ; Bones, joints and connective tissue. Antiinflammatory agents ; Disease Models, Animal ; Edema - chemically induced ; Edema - drug therapy ; Edema - prevention & control ; Foot - pathology ; Medical sciences ; Mice ; Pharmacology. Drug treatments ; Phospholipases A2 - metabolism ; Prostaglandin-Endoperoxide Synthases - metabolism ; Pyrimidines ; Pyrimidines - chemical synthesis ; Pyrimidines - chemistry ; Pyrimidines - pharmacology ; Rats ; Synthesis ; Ulcer - etiology</subject><ispartof>Bioorganic & medicinal chemistry, 2008-08, Vol.18 (15), p.4409-4412</ispartof><rights>2008 Elsevier Ltd</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-9a23faa5a3e8906e27afa2861079645b167c2cdd605ee71588b10ba7f3e4c7ba3</citedby><cites>FETCH-LOGICAL-c415t-9a23faa5a3e8906e27afa2861079645b167c2cdd605ee71588b10ba7f3e4c7ba3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bmcl.2008.06.061$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20581892$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18621525$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Venu, T.D.</creatorcontrib><creatorcontrib>Khanum, S.A.</creatorcontrib><creatorcontrib>Firdouse, Aiysha</creatorcontrib><creatorcontrib>Manuprasad, B.K.</creatorcontrib><creatorcontrib>Shashikanth, Sheena</creatorcontrib><creatorcontrib>Mohamed, Riyaz</creatorcontrib><creatorcontrib>Vishwanth, Bannikuppe Sannanaik</creatorcontrib><title>Synthesis and anti-inflammatory activity of 2-(2-aroylaroxy)-4,6-dimethoxy pyrimidines</title><title>Bioorganic & medicinal chemistry</title><addtitle>Bioorg Med Chem Lett</addtitle><description>The newly synthesized compounds 2-(2-aroylaroxy)-4,6-dimethoxy pyrimidines
7a–
f were screened for their anti-inflammatory activity and compared with standard drugs.
Abstract-Reaction of
6a–
f individually with 2-methylsulfonyl-4,6-dimethoxypyrimidine yielded
7a–
f in excellent yield. The newly synthesized heterocycles were characterized by IR,
1H NMR, and mass spectral data. Compounds
7a–
f was screened for their anti-inflammatory activity and were compared with standard drugs. Of the compounds studied, the compound
7e showed more potent activity than the standard drugs at all doses tested.</description><subject>Algorithms</subject><subject>Animals</subject><subject>Animals, Inbred Strains</subject><subject>Anti-inflammatory activity</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - chemistry</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Bones, joints and connective tissue. Antiinflammatory agents</subject><subject>Disease Models, Animal</subject><subject>Edema - chemically induced</subject><subject>Edema - drug therapy</subject><subject>Edema - prevention & control</subject><subject>Foot - pathology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Pharmacology. Drug treatments</subject><subject>Phospholipases A2 - metabolism</subject><subject>Prostaglandin-Endoperoxide Synthases - metabolism</subject><subject>Pyrimidines</subject><subject>Pyrimidines - chemical synthesis</subject><subject>Pyrimidines - chemistry</subject><subject>Pyrimidines - pharmacology</subject><subject>Rats</subject><subject>Synthesis</subject><subject>Ulcer - etiology</subject><issn>0960-894X</issn><issn>0968-0896</issn><issn>1464-3405</issn><issn>1464-3391</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE2LFDEQhoMo7rj6BzxIXxQFM1bSSTqBvcjiFyx48ANvoTpdzWbojzHpWex_b4YZ9KZQSRF46qXyMPZUwFaAMG9223YMw1YC2C2YUuIe2whlFK8V6PtsA84At079uGCPct4BCAVKPWQXwhoptNQb9v3LOi23lGOucOrKWSKPUz_gOOIyp7XCsMS7uKzV3FeSv5Qc07wO5fq1vuLqteFdHGm5Lc9qv6Y4xi5OlB-zBz0OmZ6c-yX79v7d1-uP_Obzh0_Xb294UEIv3KGse0SNNVkHhmSDPUprBDTOKN0K0wQZus6AJmqEtrYV0GLT16RC02J9yV6ccvdp_nmgvPgx5kDDgBPNh-yNq7WtrfkvKFwjGuVsAeUJDGnOOVHv9-VXmFYvwB-1-50_avdH7R5MKVGGnp3TD-1I3d-Rs-cCPD8DmAMOfcIpxPyHk6CtsE4W7urEUZF2Fyn5HCJNgbqYKCy-m-O_9vgN_32gag</recordid><startdate>20080801</startdate><enddate>20080801</enddate><creator>Venu, T.D.</creator><creator>Khanum, S.A.</creator><creator>Firdouse, Aiysha</creator><creator>Manuprasad, B.K.</creator><creator>Shashikanth, Sheena</creator><creator>Mohamed, Riyaz</creator><creator>Vishwanth, Bannikuppe Sannanaik</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20080801</creationdate><title>Synthesis and anti-inflammatory activity of 2-(2-aroylaroxy)-4,6-dimethoxy pyrimidines</title><author>Venu, T.D. ; Khanum, S.A. ; Firdouse, Aiysha ; Manuprasad, B.K. ; Shashikanth, Sheena ; Mohamed, Riyaz ; Vishwanth, Bannikuppe Sannanaik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-9a23faa5a3e8906e27afa2861079645b167c2cdd605ee71588b10ba7f3e4c7ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Algorithms</topic><topic>Animals</topic><topic>Animals, Inbred Strains</topic><topic>Anti-inflammatory activity</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - chemistry</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Bones, joints and connective tissue. Antiinflammatory agents</topic><topic>Disease Models, Animal</topic><topic>Edema - chemically induced</topic><topic>Edema - drug therapy</topic><topic>Edema - prevention & control</topic><topic>Foot - pathology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Pharmacology. Drug treatments</topic><topic>Phospholipases A2 - metabolism</topic><topic>Prostaglandin-Endoperoxide Synthases - metabolism</topic><topic>Pyrimidines</topic><topic>Pyrimidines - chemical synthesis</topic><topic>Pyrimidines - chemistry</topic><topic>Pyrimidines - pharmacology</topic><topic>Rats</topic><topic>Synthesis</topic><topic>Ulcer - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Venu, T.D.</creatorcontrib><creatorcontrib>Khanum, S.A.</creatorcontrib><creatorcontrib>Firdouse, Aiysha</creatorcontrib><creatorcontrib>Manuprasad, B.K.</creatorcontrib><creatorcontrib>Shashikanth, Sheena</creatorcontrib><creatorcontrib>Mohamed, Riyaz</creatorcontrib><creatorcontrib>Vishwanth, Bannikuppe Sannanaik</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Bioorganic & medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Venu, T.D.</au><au>Khanum, S.A.</au><au>Firdouse, Aiysha</au><au>Manuprasad, B.K.</au><au>Shashikanth, Sheena</au><au>Mohamed, Riyaz</au><au>Vishwanth, Bannikuppe Sannanaik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and anti-inflammatory activity of 2-(2-aroylaroxy)-4,6-dimethoxy pyrimidines</atitle><jtitle>Bioorganic & medicinal chemistry</jtitle><addtitle>Bioorg Med Chem Lett</addtitle><date>2008-08-01</date><risdate>2008</risdate><volume>18</volume><issue>15</issue><spage>4409</spage><epage>4412</epage><pages>4409-4412</pages><issn>0960-894X</issn><issn>0968-0896</issn><eissn>1464-3405</eissn><eissn>1464-3391</eissn><abstract>The newly synthesized compounds 2-(2-aroylaroxy)-4,6-dimethoxy pyrimidines
7a–
f were screened for their anti-inflammatory activity and compared with standard drugs.
Abstract-Reaction of
6a–
f individually with 2-methylsulfonyl-4,6-dimethoxypyrimidine yielded
7a–
f in excellent yield. The newly synthesized heterocycles were characterized by IR,
1H NMR, and mass spectral data. Compounds
7a–
f was screened for their anti-inflammatory activity and were compared with standard drugs. Of the compounds studied, the compound
7e showed more potent activity than the standard drugs at all doses tested.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>18621525</pmid><doi>10.1016/j.bmcl.2008.06.061</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry, 2008-08, Vol.18 (15), p.4409-4412 |
| issn | 0960-894X 0968-0896 1464-3405 1464-3391 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69358386 |
| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Algorithms Animals Animals, Inbred Strains Anti-inflammatory activity Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - pharmacology Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Disease Models, Animal Edema - chemically induced Edema - drug therapy Edema - prevention & control Foot - pathology Medical sciences Mice Pharmacology. Drug treatments Phospholipases A2 - metabolism Prostaglandin-Endoperoxide Synthases - metabolism Pyrimidines Pyrimidines - chemical synthesis Pyrimidines - chemistry Pyrimidines - pharmacology Rats Synthesis Ulcer - etiology |
| title | Synthesis and anti-inflammatory activity of 2-(2-aroylaroxy)-4,6-dimethoxy pyrimidines |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T08%3A24%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Synthesis%20and%20anti-inflammatory%20activity%20of%202-(2-aroylaroxy)-4,6-dimethoxy%20pyrimidines&rft.jtitle=Bioorganic%20&%20medicinal%20chemistry&rft.au=Venu,%20T.D.&rft.date=2008-08-01&rft.volume=18&rft.issue=15&rft.spage=4409&rft.epage=4412&rft.pages=4409-4412&rft.issn=0960-894X&rft.eissn=1464-3405&rft_id=info:doi/10.1016/j.bmcl.2008.06.061&rft_dat=%3Cproquest_cross%3E19717498%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=19717498&rft_id=info:pmid/18621525&rft_els_id=S0960894X08007105&rfr_iscdi=true |