Pyrazole inhibitors of coactivator associated arginine methyltransferase 1 (CARM1)

This study reports the identification and Hits to Leads optimization of inhibitors of coactivator associated arginine methyltransferase (CARM1). Compound 7b is a potent, selective inhibitor of CARM1. This study reports the identification and Hits to Leads optimization of inhibitors of coactivator as...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2008-08, Vol.18 (15), p.4438-4441
Hauptverfasser:	Purandare, Ashok V., Chen, Zhong, Huynh, Tram, Pang, Suhong, Geng, Jieping, Vaccaro, Wayne, Poss, Michael A., Oconnell, Jonathan, Nowak, Kimberly, Jayaraman, Lata
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences CARM1 Coactivator associated arginine methyltransferase 1 Combinatorial Chemistry Techniques General aspects Medical sciences Molecular Structure Pharmacology. Drug treatments PRMT4 Protein arginine methyltransferase Protein-Arginine N-Methyltransferases - antagonists & inhibitors Pyrazoles - chemical synthesis Pyrazoles - chemistry Pyrazoles - pharmacology Stereoisomerism Structure-Activity Relationship
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Zusammenfassung:	This study reports the identification and Hits to Leads optimization of inhibitors of coactivator associated arginine methyltransferase (CARM1). Compound 7b is a potent, selective inhibitor of CARM1. This study reports the identification and Hits to Leads optimization of inhibitors of coactivator associated arginine methyltransferase (CARM1). Compound 7b is a potent, selective inhibitor of CARM1.
ISSN:	0960-894X 0968-0896 1464-3405 1464-3391
DOI:	10.1016/j.bmcl.2008.06.026