Synthesis of 3-Selena-1-dethiacephems and Selenazepines via Iodocyclization

A convenient approach to synthesize novel selenium-β-lactams, 3-selena-1-dethiacephems and selenazepines, was accomplished via the regioselective iodocyclization reaction. The substituent of allenyl moieties dramatically influenced the regiochemical outcome in the iodocyclization of allene-selenoure...

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Veröffentlicht in:	Organic letters 2008-08, Vol.10 (15), p.3319-3322
Hauptverfasser:	Garud, Dinesh R, Koketsu, Mamoru
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes - chemistry Azepines - chemical synthesis beta-Lactams - chemical synthesis Cephalosporins - chemical synthesis Cyclization Iodine - chemistry Organoselenium Compounds - chemical synthesis
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	A convenient approach to synthesize novel selenium-β-lactams, 3-selena-1-dethiacephems and selenazepines, was accomplished via the regioselective iodocyclization reaction. The substituent of allenyl moieties dramatically influenced the regiochemical outcome in the iodocyclization of allene-selenourea derivatives.
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol801010y