Systolic pressure variation and pulse pressure variation during modifications of arterial pressure
Objective This study was performed to investigate the effect of vasopressor therapy on systolic pressure variation (SPV) and pulse pressure variation (PPV) compared to experimentally measured left ventricular stroke volume variation (SVV). Design and setting Prospective study in a university laborat...
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creator | Kubitz, Jens C. Forkl, Stefanie Annecke, Thorsten Kronas, Nils Goetz, Alwin E. Reuter, Daniel A. |
description | Objective
This study was performed to investigate the effect of vasopressor therapy on systolic pressure variation (SPV) and pulse pressure variation (PPV) compared to experimentally measured left ventricular stroke volume variation (SVV).
Design and setting
Prospective study in a university laboratory.
Subjects
Twelve anesthetized and mechanically ventilated pigs.
Interventions
Increase in mean arterial pressure (by 100%) using phenylephrine and decrease (by 38%) using adenosine.
Measurements and results
SPV and PPV were calculated and compared to SVV derived from aortic blood flow measurements. SPV was significantly affected by changes in arterial pressure [4.6% (1.5) vs. 6.3% (2.1),
p
|
doi_str_mv | 10.1007/s00134-008-1114-8 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69356344</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1519005371</sourcerecordid><originalsourceid>FETCH-LOGICAL-c399t-cb6f36f1ac880af11a273f24c8f0fcc09cf2965b13d9ca74f3b2b41bec521df23</originalsourceid><addsrcrecordid>eNp1kF1LwzAYhYMobk5_gDdSBL2r5n2TtumliF8w8EK9DmmaSEbX1qQV_PdmbmwgehVInnNyeAg5BXoFlBbXgVJgPKVUpADAU7FHpsAZpoBM7JMpZRxTnnOckKMQFpEu8gwOyQQEx6IoyimpXr7C0DVOJ703IYzeJJ_KOzW4rk1UWyf92ATz12M9ete-J8uudtbpn7uQdDZRfjCRabaZY3JgVSw52Zwz8nZ_93r7mM6fH55ub-apZmU5pLrKLcstKC0EVRZAYcEsci0stVrTUlss86wCVpdaFdyyCisOldEZQm2Rzcjlurf33cdowiCXLmjTNKo13RhkXrIsZ5xH8PwXuOhG38ZtEiFHFEhXEKwh7bsQvLGy926p_JcEKlf25dq-jPblyr4UMXO2KR6rpal3iY3uCFxsABW0aqxXrXZhyyHNOI0LIodrLvQrycbvFv7_-zftZZ6t</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>216228204</pqid></control><display><type>article</type><title>Systolic pressure variation and pulse pressure variation during modifications of arterial pressure</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Kubitz, Jens C. ; Forkl, Stefanie ; Annecke, Thorsten ; Kronas, Nils ; Goetz, Alwin E. ; Reuter, Daniel A.</creator><creatorcontrib>Kubitz, Jens C. ; Forkl, Stefanie ; Annecke, Thorsten ; Kronas, Nils ; Goetz, Alwin E. ; Reuter, Daniel A.</creatorcontrib><description>Objective
This study was performed to investigate the effect of vasopressor therapy on systolic pressure variation (SPV) and pulse pressure variation (PPV) compared to experimentally measured left ventricular stroke volume variation (SVV).
Design and setting
Prospective study in a university laboratory.
Subjects
Twelve anesthetized and mechanically ventilated pigs.
Interventions
Increase in mean arterial pressure (by 100%) using phenylephrine and decrease (by 38%) using adenosine.
Measurements and results
SPV and PPV were calculated and compared to SVV derived from aortic blood flow measurements. SPV was significantly affected by changes in arterial pressure [4.6% (1.5) vs. 6.3% (2.1),
p
< 0.05, increased vs. decreased arterial pressure], whereas PPV did not change during modifications of arterial pressure. During baseline conditions and decreased afterload, correlation with SVV was good both for SPV (
r
= 0.892 and
r
= 0.859, respectively) and for PPV (
r
= 0.870 and
r
= 0.871, respectively) (all
p
< 0.001). Correlation with SVV was only moderate during increased arterial pressure (
r
= 0.683 for SPV and
r
= 0.732 for PPV,
p
< 0.05).
Conclusion
For guiding fluid therapy in patients under vasopressor support, PPV seems superior to SPV.</description><identifier>ISSN: 0342-4642</identifier><identifier>EISSN: 1432-1238</identifier><identifier>DOI: 10.1007/s00134-008-1114-8</identifier><identifier>PMID: 18427779</identifier><identifier>CODEN: ICMED9</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adenosine ; Adrenergic alpha-Agonists - pharmacology ; Analysis of Variance ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Anesthesiology ; Animals ; Biological and medical sciences ; Blood Pressure - drug effects ; Critical Care Medicine ; Emergency and intensive respiratory care ; Emergency Medicine ; Experimental ; Intensive ; Intensive care medicine ; Laboratory animals ; Medical sciences ; Medicine ; Medicine & Public Health ; Pain Medicine ; Pediatrics ; Phenylephrine - pharmacology ; Pneumology/Respiratory System ; Pulmonary arteries ; Pulse ; Statistical analysis ; Stroke Volume - drug effects ; Swine ; Variance analysis ; Vasoconstrictor Agents - pharmacology</subject><ispartof>Intensive care medicine, 2008-08, Vol.34 (8), p.1520-1524</ispartof><rights>Springer-Verlag 2008</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-cb6f36f1ac880af11a273f24c8f0fcc09cf2965b13d9ca74f3b2b41bec521df23</citedby><cites>FETCH-LOGICAL-c399t-cb6f36f1ac880af11a273f24c8f0fcc09cf2965b13d9ca74f3b2b41bec521df23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00134-008-1114-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00134-008-1114-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20540162$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18427779$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kubitz, Jens C.</creatorcontrib><creatorcontrib>Forkl, Stefanie</creatorcontrib><creatorcontrib>Annecke, Thorsten</creatorcontrib><creatorcontrib>Kronas, Nils</creatorcontrib><creatorcontrib>Goetz, Alwin E.</creatorcontrib><creatorcontrib>Reuter, Daniel A.</creatorcontrib><title>Systolic pressure variation and pulse pressure variation during modifications of arterial pressure</title><title>Intensive care medicine</title><addtitle>Intensive Care Med</addtitle><addtitle>Intensive Care Med</addtitle><description>Objective
This study was performed to investigate the effect of vasopressor therapy on systolic pressure variation (SPV) and pulse pressure variation (PPV) compared to experimentally measured left ventricular stroke volume variation (SVV).
Design and setting
Prospective study in a university laboratory.
Subjects
Twelve anesthetized and mechanically ventilated pigs.
Interventions
Increase in mean arterial pressure (by 100%) using phenylephrine and decrease (by 38%) using adenosine.
Measurements and results
SPV and PPV were calculated and compared to SVV derived from aortic blood flow measurements. SPV was significantly affected by changes in arterial pressure [4.6% (1.5) vs. 6.3% (2.1),
p
< 0.05, increased vs. decreased arterial pressure], whereas PPV did not change during modifications of arterial pressure. During baseline conditions and decreased afterload, correlation with SVV was good both for SPV (
r
= 0.892 and
r
= 0.859, respectively) and for PPV (
r
= 0.870 and
r
= 0.871, respectively) (all
p
< 0.001). Correlation with SVV was only moderate during increased arterial pressure (
r
= 0.683 for SPV and
r
= 0.732 for PPV,
p
< 0.05).
Conclusion
For guiding fluid therapy in patients under vasopressor support, PPV seems superior to SPV.</description><subject>Adenosine</subject><subject>Adrenergic alpha-Agonists - pharmacology</subject><subject>Analysis of Variance</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Anesthesiology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Critical Care Medicine</subject><subject>Emergency and intensive respiratory care</subject><subject>Emergency Medicine</subject><subject>Experimental</subject><subject>Intensive</subject><subject>Intensive care medicine</subject><subject>Laboratory animals</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Pain Medicine</subject><subject>Pediatrics</subject><subject>Phenylephrine - pharmacology</subject><subject>Pneumology/Respiratory System</subject><subject>Pulmonary arteries</subject><subject>Pulse</subject><subject>Statistical analysis</subject><subject>Stroke Volume - drug effects</subject><subject>Swine</subject><subject>Variance analysis</subject><subject>Vasoconstrictor Agents - pharmacology</subject><issn>0342-4642</issn><issn>1432-1238</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kF1LwzAYhYMobk5_gDdSBL2r5n2TtumliF8w8EK9DmmaSEbX1qQV_PdmbmwgehVInnNyeAg5BXoFlBbXgVJgPKVUpADAU7FHpsAZpoBM7JMpZRxTnnOckKMQFpEu8gwOyQQEx6IoyimpXr7C0DVOJ703IYzeJJ_KOzW4rk1UWyf92ATz12M9ete-J8uudtbpn7uQdDZRfjCRabaZY3JgVSw52Zwz8nZ_93r7mM6fH55ub-apZmU5pLrKLcstKC0EVRZAYcEsci0stVrTUlss86wCVpdaFdyyCisOldEZQm2Rzcjlurf33cdowiCXLmjTNKo13RhkXrIsZ5xH8PwXuOhG38ZtEiFHFEhXEKwh7bsQvLGy926p_JcEKlf25dq-jPblyr4UMXO2KR6rpal3iY3uCFxsABW0aqxXrXZhyyHNOI0LIodrLvQrycbvFv7_-zftZZ6t</recordid><startdate>20080801</startdate><enddate>20080801</enddate><creator>Kubitz, Jens C.</creator><creator>Forkl, Stefanie</creator><creator>Annecke, Thorsten</creator><creator>Kronas, Nils</creator><creator>Goetz, Alwin E.</creator><creator>Reuter, Daniel A.</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20080801</creationdate><title>Systolic pressure variation and pulse pressure variation during modifications of arterial pressure</title><author>Kubitz, Jens C. ; Forkl, Stefanie ; Annecke, Thorsten ; Kronas, Nils ; Goetz, Alwin E. ; Reuter, Daniel A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-cb6f36f1ac880af11a273f24c8f0fcc09cf2965b13d9ca74f3b2b41bec521df23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adenosine</topic><topic>Adrenergic alpha-Agonists - pharmacology</topic><topic>Analysis of Variance</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Anesthesiology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Critical Care Medicine</topic><topic>Emergency and intensive respiratory care</topic><topic>Emergency Medicine</topic><topic>Experimental</topic><topic>Intensive</topic><topic>Intensive care medicine</topic><topic>Laboratory animals</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Pain Medicine</topic><topic>Pediatrics</topic><topic>Phenylephrine - pharmacology</topic><topic>Pneumology/Respiratory System</topic><topic>Pulmonary arteries</topic><topic>Pulse</topic><topic>Statistical analysis</topic><topic>Stroke Volume - drug effects</topic><topic>Swine</topic><topic>Variance analysis</topic><topic>Vasoconstrictor Agents - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kubitz, Jens C.</creatorcontrib><creatorcontrib>Forkl, Stefanie</creatorcontrib><creatorcontrib>Annecke, Thorsten</creatorcontrib><creatorcontrib>Kronas, Nils</creatorcontrib><creatorcontrib>Goetz, Alwin E.</creatorcontrib><creatorcontrib>Reuter, Daniel A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Intensive care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kubitz, Jens C.</au><au>Forkl, Stefanie</au><au>Annecke, Thorsten</au><au>Kronas, Nils</au><au>Goetz, Alwin E.</au><au>Reuter, Daniel A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Systolic pressure variation and pulse pressure variation during modifications of arterial pressure</atitle><jtitle>Intensive care medicine</jtitle><stitle>Intensive Care Med</stitle><addtitle>Intensive Care Med</addtitle><date>2008-08-01</date><risdate>2008</risdate><volume>34</volume><issue>8</issue><spage>1520</spage><epage>1524</epage><pages>1520-1524</pages><issn>0342-4642</issn><eissn>1432-1238</eissn><coden>ICMED9</coden><abstract>Objective
This study was performed to investigate the effect of vasopressor therapy on systolic pressure variation (SPV) and pulse pressure variation (PPV) compared to experimentally measured left ventricular stroke volume variation (SVV).
Design and setting
Prospective study in a university laboratory.
Subjects
Twelve anesthetized and mechanically ventilated pigs.
Interventions
Increase in mean arterial pressure (by 100%) using phenylephrine and decrease (by 38%) using adenosine.
Measurements and results
SPV and PPV were calculated and compared to SVV derived from aortic blood flow measurements. SPV was significantly affected by changes in arterial pressure [4.6% (1.5) vs. 6.3% (2.1),
p
< 0.05, increased vs. decreased arterial pressure], whereas PPV did not change during modifications of arterial pressure. During baseline conditions and decreased afterload, correlation with SVV was good both for SPV (
r
= 0.892 and
r
= 0.859, respectively) and for PPV (
r
= 0.870 and
r
= 0.871, respectively) (all
p
< 0.001). Correlation with SVV was only moderate during increased arterial pressure (
r
= 0.683 for SPV and
r
= 0.732 for PPV,
p
< 0.05).
Conclusion
For guiding fluid therapy in patients under vasopressor support, PPV seems superior to SPV.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>18427779</pmid><doi>10.1007/s00134-008-1114-8</doi><tpages>5</tpages></addata></record> |
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language | eng |
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source | MEDLINE; SpringerLink Journals - AutoHoldings |
subjects | Adenosine Adrenergic alpha-Agonists - pharmacology Analysis of Variance Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anesthesiology Animals Biological and medical sciences Blood Pressure - drug effects Critical Care Medicine Emergency and intensive respiratory care Emergency Medicine Experimental Intensive Intensive care medicine Laboratory animals Medical sciences Medicine Medicine & Public Health Pain Medicine Pediatrics Phenylephrine - pharmacology Pneumology/Respiratory System Pulmonary arteries Pulse Statistical analysis Stroke Volume - drug effects Swine Variance analysis Vasoconstrictor Agents - pharmacology |
title | Systolic pressure variation and pulse pressure variation during modifications of arterial pressure |
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