Systolic pressure variation and pulse pressure variation during modifications of arterial pressure

Objective This study was performed to investigate the effect of vasopressor therapy on systolic pressure variation (SPV) and pulse pressure variation (PPV) compared to experimentally measured left ventricular stroke volume variation (SVV). Design and setting Prospective study in a university laborat...

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Veröffentlicht in:Intensive care medicine 2008-08, Vol.34 (8), p.1520-1524
Hauptverfasser: Kubitz, Jens C., Forkl, Stefanie, Annecke, Thorsten, Kronas, Nils, Goetz, Alwin E., Reuter, Daniel A.
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container_end_page 1524
container_issue 8
container_start_page 1520
container_title Intensive care medicine
container_volume 34
creator Kubitz, Jens C.
Forkl, Stefanie
Annecke, Thorsten
Kronas, Nils
Goetz, Alwin E.
Reuter, Daniel A.
description Objective This study was performed to investigate the effect of vasopressor therapy on systolic pressure variation (SPV) and pulse pressure variation (PPV) compared to experimentally measured left ventricular stroke volume variation (SVV). Design and setting Prospective study in a university laboratory. Subjects Twelve anesthetized and mechanically ventilated pigs. Interventions Increase in mean arterial pressure (by 100%) using phenylephrine and decrease (by 38%) using adenosine. Measurements and results SPV and PPV were calculated and compared to SVV derived from aortic blood flow measurements. SPV was significantly affected by changes in arterial pressure [4.6% (1.5) vs. 6.3% (2.1), p  
doi_str_mv 10.1007/s00134-008-1114-8
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Design and setting Prospective study in a university laboratory. Subjects Twelve anesthetized and mechanically ventilated pigs. Interventions Increase in mean arterial pressure (by 100%) using phenylephrine and decrease (by 38%) using adenosine. Measurements and results SPV and PPV were calculated and compared to SVV derived from aortic blood flow measurements. SPV was significantly affected by changes in arterial pressure [4.6% (1.5) vs. 6.3% (2.1), p  &lt; 0.05, increased vs. decreased arterial pressure], whereas PPV did not change during modifications of arterial pressure. During baseline conditions and decreased afterload, correlation with SVV was good both for SPV ( r  = 0.892 and r  = 0.859, respectively) and for PPV ( r  = 0.870 and r  = 0.871, respectively) (all p  &lt; 0.001). Correlation with SVV was only moderate during increased arterial pressure ( r  = 0.683 for SPV and r  = 0.732 for PPV, p  &lt; 0.05). Conclusion For guiding fluid therapy in patients under vasopressor support, PPV seems superior to SPV.</description><identifier>ISSN: 0342-4642</identifier><identifier>EISSN: 1432-1238</identifier><identifier>DOI: 10.1007/s00134-008-1114-8</identifier><identifier>PMID: 18427779</identifier><identifier>CODEN: ICMED9</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adenosine ; Adrenergic alpha-Agonists - pharmacology ; Analysis of Variance ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Anesthesiology ; Animals ; Biological and medical sciences ; Blood Pressure - drug effects ; Critical Care Medicine ; Emergency and intensive respiratory care ; Emergency Medicine ; Experimental ; Intensive ; Intensive care medicine ; Laboratory animals ; Medical sciences ; Medicine ; Medicine &amp; Public Health ; Pain Medicine ; Pediatrics ; Phenylephrine - pharmacology ; Pneumology/Respiratory System ; Pulmonary arteries ; Pulse ; Statistical analysis ; Stroke Volume - drug effects ; Swine ; Variance analysis ; Vasoconstrictor Agents - pharmacology</subject><ispartof>Intensive care medicine, 2008-08, Vol.34 (8), p.1520-1524</ispartof><rights>Springer-Verlag 2008</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-cb6f36f1ac880af11a273f24c8f0fcc09cf2965b13d9ca74f3b2b41bec521df23</citedby><cites>FETCH-LOGICAL-c399t-cb6f36f1ac880af11a273f24c8f0fcc09cf2965b13d9ca74f3b2b41bec521df23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00134-008-1114-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00134-008-1114-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=20540162$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18427779$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kubitz, Jens C.</creatorcontrib><creatorcontrib>Forkl, Stefanie</creatorcontrib><creatorcontrib>Annecke, Thorsten</creatorcontrib><creatorcontrib>Kronas, Nils</creatorcontrib><creatorcontrib>Goetz, Alwin E.</creatorcontrib><creatorcontrib>Reuter, Daniel A.</creatorcontrib><title>Systolic pressure variation and pulse pressure variation during modifications of arterial pressure</title><title>Intensive care medicine</title><addtitle>Intensive Care Med</addtitle><addtitle>Intensive Care Med</addtitle><description>Objective This study was performed to investigate the effect of vasopressor therapy on systolic pressure variation (SPV) and pulse pressure variation (PPV) compared to experimentally measured left ventricular stroke volume variation (SVV). Design and setting Prospective study in a university laboratory. Subjects Twelve anesthetized and mechanically ventilated pigs. Interventions Increase in mean arterial pressure (by 100%) using phenylephrine and decrease (by 38%) using adenosine. Measurements and results SPV and PPV were calculated and compared to SVV derived from aortic blood flow measurements. SPV was significantly affected by changes in arterial pressure [4.6% (1.5) vs. 6.3% (2.1), p  &lt; 0.05, increased vs. decreased arterial pressure], whereas PPV did not change during modifications of arterial pressure. During baseline conditions and decreased afterload, correlation with SVV was good both for SPV ( r  = 0.892 and r  = 0.859, respectively) and for PPV ( r  = 0.870 and r  = 0.871, respectively) (all p  &lt; 0.001). Correlation with SVV was only moderate during increased arterial pressure ( r  = 0.683 for SPV and r  = 0.732 for PPV, p  &lt; 0.05). 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Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Anesthesiology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Critical Care Medicine</topic><topic>Emergency and intensive respiratory care</topic><topic>Emergency Medicine</topic><topic>Experimental</topic><topic>Intensive</topic><topic>Intensive care medicine</topic><topic>Laboratory animals</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Pain Medicine</topic><topic>Pediatrics</topic><topic>Phenylephrine - pharmacology</topic><topic>Pneumology/Respiratory System</topic><topic>Pulmonary arteries</topic><topic>Pulse</topic><topic>Statistical analysis</topic><topic>Stroke Volume - drug effects</topic><topic>Swine</topic><topic>Variance analysis</topic><topic>Vasoconstrictor Agents - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kubitz, Jens C.</creatorcontrib><creatorcontrib>Forkl, Stefanie</creatorcontrib><creatorcontrib>Annecke, Thorsten</creatorcontrib><creatorcontrib>Kronas, Nils</creatorcontrib><creatorcontrib>Goetz, Alwin E.</creatorcontrib><creatorcontrib>Reuter, Daniel A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing &amp; Allied Health Database</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Intensive care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kubitz, Jens C.</au><au>Forkl, Stefanie</au><au>Annecke, Thorsten</au><au>Kronas, Nils</au><au>Goetz, Alwin E.</au><au>Reuter, Daniel A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Systolic pressure variation and pulse pressure variation during modifications of arterial pressure</atitle><jtitle>Intensive care medicine</jtitle><stitle>Intensive Care Med</stitle><addtitle>Intensive Care Med</addtitle><date>2008-08-01</date><risdate>2008</risdate><volume>34</volume><issue>8</issue><spage>1520</spage><epage>1524</epage><pages>1520-1524</pages><issn>0342-4642</issn><eissn>1432-1238</eissn><coden>ICMED9</coden><abstract>Objective This study was performed to investigate the effect of vasopressor therapy on systolic pressure variation (SPV) and pulse pressure variation (PPV) compared to experimentally measured left ventricular stroke volume variation (SVV). Design and setting Prospective study in a university laboratory. Subjects Twelve anesthetized and mechanically ventilated pigs. Interventions Increase in mean arterial pressure (by 100%) using phenylephrine and decrease (by 38%) using adenosine. Measurements and results SPV and PPV were calculated and compared to SVV derived from aortic blood flow measurements. SPV was significantly affected by changes in arterial pressure [4.6% (1.5) vs. 6.3% (2.1), p  &lt; 0.05, increased vs. decreased arterial pressure], whereas PPV did not change during modifications of arterial pressure. During baseline conditions and decreased afterload, correlation with SVV was good both for SPV ( r  = 0.892 and r  = 0.859, respectively) and for PPV ( r  = 0.870 and r  = 0.871, respectively) (all p  &lt; 0.001). Correlation with SVV was only moderate during increased arterial pressure ( r  = 0.683 for SPV and r  = 0.732 for PPV, p  &lt; 0.05). Conclusion For guiding fluid therapy in patients under vasopressor support, PPV seems superior to SPV.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>18427779</pmid><doi>10.1007/s00134-008-1114-8</doi><tpages>5</tpages></addata></record>
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subjects Adenosine
Adrenergic alpha-Agonists - pharmacology
Analysis of Variance
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Anesthesiology
Animals
Biological and medical sciences
Blood Pressure - drug effects
Critical Care Medicine
Emergency and intensive respiratory care
Emergency Medicine
Experimental
Intensive
Intensive care medicine
Laboratory animals
Medical sciences
Medicine
Medicine & Public Health
Pain Medicine
Pediatrics
Phenylephrine - pharmacology
Pneumology/Respiratory System
Pulmonary arteries
Pulse
Statistical analysis
Stroke Volume - drug effects
Swine
Variance analysis
Vasoconstrictor Agents - pharmacology
title Systolic pressure variation and pulse pressure variation during modifications of arterial pressure
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