Systolic pressure variation and pulse pressure variation during modifications of arterial pressure

Objective This study was performed to investigate the effect of vasopressor therapy on systolic pressure variation (SPV) and pulse pressure variation (PPV) compared to experimentally measured left ventricular stroke volume variation (SVV). Design and setting Prospective study in a university laboratory. Subjects Twelve anesthetized and mechanically ventilated pigs. Interventions Increase in mean arterial pressure (by 100%) using phenylephrine and decrease (by 38%) using adenosine. Measurements and results SPV and PPV were calculated and compared to SVV derived from aortic blood flow measurements. SPV was significantly affected by changes in arterial pressure [4.6% (1.5) vs. 6.3% (2.1), p