Unraveling the ribbon synapse

A new study identifies pikachurin, a previously-unknown dystroglycan-binding protein that is critical for the apposition of photoreceptor and bipolar cell dendrites at the ribbon synapse. This work could explain some of the visual defects seen in several muscular dystrophies.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature neuroscience 2008-08, Vol.11 (8), p.857-859
Hauptverfasser:	Satz, Jakob S, Campbell, Kevin P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Genetics and Genomics Animals Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Dystroglycans - metabolism Dystrophin - genetics Dystrophin - metabolism Eye Proteins - genetics Eye Proteins - physiology Humans Mice Mice, Knockout Muscular Dystrophies - genetics Muscular Dystrophies - metabolism Muscular dystrophy Neurobiology Neurosciences news-and-views Photoreceptor Cells - physiology Photoreceptors Physiological aspects Retina - embryology Retina - physiology Retinal Bipolar Cells - physiology Retinal Horizontal Cells - physiology Risk factors Synapses Synapses - genetics Synapses - physiology Synapses - ultrastructure
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Beschreibung
Zusammenfassung:	A new study identifies pikachurin, a previously-unknown dystroglycan-binding protein that is critical for the apposition of photoreceptor and bipolar cell dendrites at the ribbon synapse. This work could explain some of the visual defects seen in several muscular dystrophies.
ISSN:	1097-6256 1546-1726
DOI:	10.1038/nn0808-857