Chronic exposure to hypoxia attenuates contractile responses in rat airways in vitro: a possible role for nitric oxide

We investigated the effect of chronic hypoxia (10% O 2 for 14 days) on airway responsiveness in rats. Chronic hypoxia significantly ( P

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Veröffentlicht in:	European journal of pharmacology 1999-11, Vol.385 (1), p.29-37
Hauptverfasser:	Clayton, Robert A, Nally, Jane E, MacLean, Margaret R, Thomson, Neil C, McGrath, John C
Format:	Artikel
Sprache:	eng
Schlagworte:	Airway reactivity Albuterol - pharmacology Animals Biological and medical sciences Bronchi - drug effects Bronchi - physiopathology Bronchoconstrictor Agents - pharmacology Bronchodilator Agents - pharmacology Cyclooxygenase Inhibitors - pharmacology Dose-Response Relationship, Drug Endothelin-1 Endothelin-1 - pharmacology Enzyme Inhibitors - pharmacology Epithelium Epithelium - physiology Hypoxia - physiopathology In Vitro Techniques Indomethacin Indomethacin - pharmacology Male Medical sciences Methacholine Methacholine Chloride - pharmacology Muscle Contraction - drug effects Muscle Contraction - physiology Muscle Relaxation - drug effects NG-Nitroarginine Methyl Ester - pharmacology Nitric oxide (NO) Nitric Oxide - physiology Nitric Oxide Synthase - antagonists & inhibitors Nitroprusside - pharmacology Pneumology Potassium Chloride - pharmacology Rats Rats, Wistar Respiratory system : syndromes and miscellaneous diseases Trachea - drug effects Trachea - physiopathology
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Zusammenfassung:	We investigated the effect of chronic hypoxia (10% O 2 for 14 days) on airway responsiveness in rats. Chronic hypoxia significantly ( P
ISSN:	0014-2999 1879-0712
DOI:	10.1016/S0014-2999(99)00693-7