Peroxisome Proliferator–Activated Receptor γ Gene Locus Is Related to Body Mass Index and Lipid Values in Healthy Nonobese Subjects

The peroxisome proliferator–activated receptor γ (PPARγ) gene has been implicated in morbid obesity and is important to lipid and carbohydrate metabolism. However, the relevance of gene variations in healthy nonobese subjects has not been defined. We recruited monozygotic and dizygotic healthy nonobese twin subjects to test the hypothesis that the PPARγ gene is important to body mass index and lipid concentrations in healthy nonobese subjects. Both linkage and association strategies were used in the same dizygotic twins. The PPARγ gene locus was linked (P