Does hyperlipidemia injure the kidney?

A relationship between disturbed lipid metabolism and kidney disease was first postulated in 1858. Over the years, many animal studies have indicated that lipids have a pathophysiologic role in renal disease. The authors of this Viewpoint describe the possible mechanisms through which lipids might p...

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Veröffentlicht in:	Nature clinical practice. Nephrology 2008-08, Vol.4 (8), p.424-425
Hauptverfasser:	Grone, Elisabeth F, Grone, Hermann-Josef
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cancer research Cholesterol Complications and side effects Cytokines Diagnosis Enzymes Experiments Extracellular matrix Glomerulosclerosis, Focal Segmental - physiopathology Growth factors Humans Hyperlipidemia Hyperlipidemias - physiopathology Hypertension Kidney - physiopathology Kidney diseases Kidney Diseases - physiopathology Kidney Glomerulus - physiopathology Lipids Lipoproteins Medical research Medicine Medicine & Public Health Metabolism Nephrology Pathology Proteins Reactive Oxygen Species - metabolism Risk factors Smooth muscle Transcription factors viewpoint
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Beschreibung
Zusammenfassung:	A relationship between disturbed lipid metabolism and kidney disease was first postulated in 1858. Over the years, many animal studies have indicated that lipids have a pathophysiologic role in renal disease. The authors of this Viewpoint describe the possible mechanisms through which lipids might promote the progression of glomerular and tubulointerstitial diseases.
ISSN:	1745-8323 1759-5061 1745-8331 1759-507X
DOI:	10.1038/ncpneph0863