Treatment of severe status asthmaticus with nitric oxide

The paper reports on a 13‐year‐old girl with chronic asthma who presented in acute respiratory failure following an exacerbation of her disease. Nitric oxide was added to the ventilator circuit at 7 ppm and then 15 ppm after the patient failed to respond to bronchodilators and steroids. This was fol...

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Veröffentlicht in:	Pediatric pulmonology 1999-12, Vol.28 (6), p.451-453
Hauptverfasser:	Rishani, Rania, El-Khatib, Mohamad, Mroueh, Salman
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Adolescent Biological and medical sciences Blood Gas Analysis bronchodilation Bronchodilator Agents - administration & dosage Female Follow-Up Studies Humans Medical sciences nitric oxide Nitric Oxide - administration & dosage Pharmacology. Drug treatments Respiration, Artificial Respiratory system Severity of Illness Index status asthmaticus Status Asthmaticus - diagnosis Status Asthmaticus - drug therapy Status Asthmaticus - physiopathology Treatment Outcome
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Zusammenfassung:	The paper reports on a 13‐year‐old girl with chronic asthma who presented in acute respiratory failure following an exacerbation of her disease. Nitric oxide was added to the ventilator circuit at 7 ppm and then 15 ppm after the patient failed to respond to bronchodilators and steroids. This was followed by rapid improvement in respiratory mechanics and blood gases with no adverse effects. Nitric oxide appears to have a direct relaxing effect on the bronchial smooth muscle. Pediatr Pulmonol. 1999; 28:451–453. © 1999 Wiley‐Liss, Inc.
ISSN:	8755-6863 1099-0496
DOI:	10.1002/(SICI)1099-0496(199912)28:6<451::AID-PPUL12>3.0.CO;2-0