Renal N(epsilon)-carboxymethyllysine deposition after kidney transplantation

Accumulation of advanced glycation end products, that is, N(epsilon)-carboxymethyllysine (CML), induces oxidative stress and inflammation, and is present in chronic renal failure. Proximal tubular cells (PTCs) take up advanced glycation end products-bound proteins by apical megalin-receptors and deg...

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Veröffentlicht in:	Transplantation 2008-07, Vol.86 (2), p.330-335
Hauptverfasser:	Baumann, Marcus, Caron, Marjolein, Schmaderer, Christoph, Schulte, Christian, Viklicky, Ondreij, von Weyhern, Claus Werner Hann, Lutz, Jens, Heemann, Uwe
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biopsy Humans Inflammation Kidney - metabolism Kidney Transplantation - adverse effects Kidney Tubules - cytology Low Density Lipoprotein Receptor-Related Protein-2 - metabolism Lysine - analogs & derivatives Lysine - metabolism Male Oxidative Stress Rats Rats, Inbred F344 Rats, Inbred Lew Species Specificity
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