In-vitro susceptibility of Aspergillus spp. isolates to amphotericin B and itraconazole

The MICs of amphotericin B and itraconazole for 230 isolates of Aspergillus spp., comprising 156 Aspergillus fumigatus, 20 Aspergillus terreus, 22 Aspergillus flavus, 17 Aspergillus nidulans and 15 Aspergillus niger, were determined by a broth microdilution method with RPMI 1640 medium. No isolate w...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 1999-10, Vol.44 (4), p.553-555
Hauptverfasser:	DANNAOUI, E, PERSAT, F, MONIER, M.-F, BOREL, E, PIENS, M.-A, PICOT, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphotericin B - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antifungal Agents - pharmacology Aspergillus Aspergillus - drug effects Biological and medical sciences Humans Itraconazole - pharmacology Medical sciences Microbial Sensitivity Tests Pharmacology. Drug treatments
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Zusammenfassung:	The MICs of amphotericin B and itraconazole for 230 isolates of Aspergillus spp., comprising 156 Aspergillus fumigatus, 20 Aspergillus terreus, 22 Aspergillus flavus, 17 Aspergillus nidulans and 15 Aspergillus niger, were determined by a broth microdilution method with RPMI 1640 medium. No isolate was detected with an MIC of amphotericin B >2 mg/L. Itraconazole MICs >16 mg/L were detected for four Aspergillus fumigatus and one Aspergillus nidulans isolates.
ISSN:	0305-7453 1460-2091
DOI:	10.1093/jac/44.4.553