Rhodopeptins (Mer-N1033), Novel Cyclic Tetrapeptides with Antifungal Activity from Rhodococcus sp: I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities
Five novel cyclic tetrapeptides, named rhodopeptin Cl, C2, C3, C4 and B5, were isolated from a strain named Rhodococcus sp. Mer-N1033. They are a novel type of cyclic tetrapeptide composed of a β-amino acid and three usual α-amino acids. Rhodopeptins show high in vitro antifungal activity against Ca...
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| Veröffentlicht in: | Journal of antibiotics 1999/08/25, Vol.52(8), pp.695-699 |
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| container_title | Journal of antibiotics |
| container_volume | 52 |
| creator | CHIBA, HIROYUKI AGEMATU, HITOSI KANETO, REI TERASAWA, TADASHI SAKAI, KAZUYA DOBASHI, KAZUYUKI YOSHIOKA, TAKEO |
| description | Five novel cyclic tetrapeptides, named rhodopeptin Cl, C2, C3, C4 and B5, were isolated from a strain named Rhodococcus sp. Mer-N1033. They are a novel type of cyclic tetrapeptide composed of a β-amino acid and three usual α-amino acids. Rhodopeptins show high in vitro antifungal activity against Candida albicans and Cryptococcus neoformans, whereas they show no activity against bacteria. |
| doi_str_mv | 10.7164/antibiotics.52.695 |
| format | Article |
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| ispartof | The Journal of Antibiotics, 1999/08/25, Vol.52(8), pp.695-699 |
| issn | 0021-8820 1881-1469 |
| language | eng |
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| subjects | Animals Antibiotics (antibacterial agents, antifungal agents) Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antifungal Agents - chemistry Antifungal Agents - isolation & purification Antifungal Agents - pharmacology Applied microbiology Biological and medical sciences Candida albicans Candida albicans - drug effects Drug Evaluation, Preclinical Fermentation Fundamental and applied biological sciences. Psychology Leukemia L1210 - drug therapy Medical sciences Microbial Sensitivity Tests Microbiology Peptides, Cyclic - chemistry Peptides, Cyclic - isolation & purification Peptides, Cyclic - pharmacology Pharmacology. Drug treatments Rhodococcus Rhodococcus - classification Rhodococcus - metabolism rhodopeptin B5 rhodopeptin C1 rhodopeptin C2 rhodopeptin C3 rhodopeptin C4 |
| title | Rhodopeptins (Mer-N1033), Novel Cyclic Tetrapeptides with Antifungal Activity from Rhodococcus sp: I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities |
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