Rhodopeptins (Mer-N1033), Novel Cyclic Tetrapeptides with Antifungal Activity from Rhodococcus sp: I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities

Five novel cyclic tetrapeptides, named rhodopeptin Cl, C2, C3, C4 and B5, were isolated from a strain named Rhodococcus sp. Mer-N1033. They are a novel type of cyclic tetrapeptide composed of a β-amino acid and three usual α-amino acids. Rhodopeptins show high in vitro antifungal activity against Ca...

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Veröffentlicht in:	Journal of antibiotics 1999/08/25, Vol.52(8), pp.695-699
Hauptverfasser:	CHIBA, HIROYUKI, AGEMATU, HITOSI, KANETO, REI, TERASAWA, TADASHI, SAKAI, KAZUYA, DOBASHI, KAZUYUKI, YOSHIOKA, TAKEO
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics (antibacterial agents, antifungal agents) Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antifungal Agents - chemistry Antifungal Agents - isolation & purification Antifungal Agents - pharmacology Applied microbiology Biological and medical sciences Candida albicans Candida albicans - drug effects Drug Evaluation, Preclinical Fermentation Fundamental and applied biological sciences. Psychology Leukemia L1210 - drug therapy Medical sciences Microbial Sensitivity Tests Microbiology Peptides, Cyclic - chemistry Peptides, Cyclic - isolation & purification Peptides, Cyclic - pharmacology Pharmacology. Drug treatments Rhodococcus Rhodococcus - classification Rhodococcus - metabolism rhodopeptin B5 rhodopeptin C1 rhodopeptin C2 rhodopeptin C3 rhodopeptin C4
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Zusammenfassung:	Five novel cyclic tetrapeptides, named rhodopeptin Cl, C2, C3, C4 and B5, were isolated from a strain named Rhodococcus sp. Mer-N1033. They are a novel type of cyclic tetrapeptide composed of a β-amino acid and three usual α-amino acids. Rhodopeptins show high in vitro antifungal activity against Candida albicans and Cryptococcus neoformans, whereas they show no activity against bacteria.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.52.695