The antigen 85 complex vaccine against experimental Mycobacterium leprae infection in mice

The proteins in culture filtrate derived from Bacillus Calmette–Guérin (BCG) were examined for protection against infection by Mycobacterium leprae. Immunization with the major secreted proteins, antigen 85 complex (Ag 85) A, B and C, induced effective protective immunity against multiplication of M...

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Veröffentlicht in:	Vaccine 1999-12, Vol.18 (9), p.795-798
Hauptverfasser:	Naito, Mariko, Matsuoka, Masanori, Ohara, Naoya, Nomaguchi, Hiroko, Yamada, Takeshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Ag 85 Animals antigen 85 Antigens, Bacterial Bacterial Vaccines Bacteriology Biological and medical sciences Fundamental and applied biological sciences. Psychology Interferon-gamma - biosynthesis Leprosy Leprosy - prevention & control Mice Mice, Inbred BALB C Mice, Nude Microbiology Mycobacterium leprae Mycobacterium leprae - immunology Spleen - drug effects Spleen - immunology Vaccine Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies
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Zusammenfassung:	The proteins in culture filtrate derived from Bacillus Calmette–Guérin (BCG) were examined for protection against infection by Mycobacterium leprae. Immunization with the major secreted proteins, antigen 85 complex (Ag 85) A, B and C, induced effective protective immunity against multiplication of M. leprae in the foot pads of mice. The most effective protection was observed when mice were immunized with Ag 85A. A single immunization with Ag 85 could induce antigen-specific interferon γ (IFNγ) synthesis and more effective protection than live BCG vaccine. This study demonstrates that Ag 85 is an important immunoprotective molecule against leprosy infection.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/S0264-410X(99)00327-8