CTLA-4 gene polymorphisms predispose to autoimmune endocrinopathies but not to celiac disease

CTLA-4 gene polymorphisms predispose to autoimmune endocrinopathies but not to celiac disease

The aim of the study was to determine the association of two CTLA-4 gene polymorphisms (CT60, +49 A/G) with Hashimoto thyroiditis (HT), type 1 diabetes mellitus (T1DM) and celiac disease (CD) as well as with the occurrence of multi-organ involvement by autoimmunity in children. Genotyping was done b...

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Veröffentlicht in:Neuro-endocrinology letters 2008-06, Vol.29 (3), p.334-340
Hauptverfasser: Dallos, Tomás, Avbelj, Magdalena, Barák, L'ubomír, Zapletalová, Jirina, Pribilincová, Zuzana, Krajcírová, Mária, Kostálová, L'udmila, Battelino, Tadej, Kovács, László
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Alleles
Antigens, CD - genetics
Autoimmune Diseases - epidemiology
Autoimmune Diseases - genetics
Celiac Disease - epidemiology
Celiac Disease - genetics
Child
Cohort Studies
CTLA-4 Antigen
Diabetes Mellitus, Type 1 - epidemiology
Diabetes Mellitus, Type 1 - genetics
Endocrine System Diseases - epidemiology
Endocrine System Diseases - genetics
Female
Genetic Markers
Genotype
Humans
Male
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length - genetics
Polymorphism, Single Nucleotide - genetics
Reverse Transcriptase Polymerase Chain Reaction
Slovakia - epidemiology
Slovenia - epidemiology
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Zusammenfassung:The aim of the study was to determine the association of two CTLA-4 gene polymorphisms (CT60, +49 A/G) with Hashimoto thyroiditis (HT), type 1 diabetes mellitus (T1DM) and celiac disease (CD) as well as with the occurrence of multi-organ involvement by autoimmunity in children. Genotyping was done by RFLP analysis in Slovak children with HT (n=63) and CD (n=120) and both Slovak and Slovene children with T1DM (n=320) and healthy controls (n=231). We found a significant association of the G allele of the CT60 polymorphism with HT (p
ISSN:0172-780X