New biphenyl compounds with DNA strand-scission activity from Clusia paralicola

Three new biphenyl derivatives, clusiparalicolines A (1), B (2), and C (3), were isolated from the roots of Clusia paralicola by bioassay-directed fractionation using the DNA strand-scission and the KB human cancer cell line cytotoxicity assays. Compounds 1 and 2 were found to be active in the DNA s...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 1999-11, Vol.62 (11), p.1484-1487
Hauptverfasser:	Seo, E.K, Huang, L, Wall, M.E, Wani, M.C, Navarro, H, Mukherjee, R, Farnsworth, N.R, Konghorn, A.D
Format:	Artikel
Sprache:	eng
Schlagworte:	antineoplastic agents Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Benzopyrans - isolation & purification Benzopyrans - pharmacology Biological and medical sciences biphenyl Catechols - isolation & purification Catechols - pharmacology cell lines Cell Survival - drug effects Central America chemical constituents of plants chemical structure chromosome breakage Clusia clusiparalicolines cytotoxic compounds derivatives DNA DNA, Neoplasm - drug effects General pharmacology Humans kb cell lines KB Cells Magnetic Resonance Spectroscopy Medical sciences medicinal plants Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phenols - isolation & purification Phenols - pharmacology Plant Roots - chemistry Plants, Medicinal - chemistry roots South America spectral analysis Spectrophotometry, Infrared
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Zusammenfassung:	Three new biphenyl derivatives, clusiparalicolines A (1), B (2), and C (3), were isolated from the roots of Clusia paralicola by bioassay-directed fractionation using the DNA strand-scission and the KB human cancer cell line cytotoxicity assays. Compounds 1 and 2 were found to be active in the DNA strand-scission assay, whereas all three compounds exhibited modest cytotoxicity against the KB cell line. The structures of 1-3 were elucidated by spectroscopic methods including 1D and 2D NMR techniques.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np9900775