Fluorescent Core/Shell Nanoparticles for Specific Cell-Nucleus Staining

Fluorescent Core/Shell Nanoparticles for Specific Cell-Nucleus Staining

Water‐soluble fluorescent core/shell nanoparticles containing multiple ‐COOH groups are synthesized via atom‐transfer radical polymerization by applying perylenediimide derivatives as the template. This novel dye combines good water‐solubility and attractive optical properties. It specifically stain...

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Veröffentlicht in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2008-07, Vol.4 (7), p.894-898
Hauptverfasser: Yin, Meizhen, Shen, Jie, Gropeanu, Radu, Pflugfelder, Gert O., Weil, Tanja, Müllen, Klaus
Format: Artikel
Sprache:eng
Schlagworte:
carboxylic acid
Carboxylic Acids - chemistry
cell nucleus
Cell Nucleus - metabolism
Coloring Agents - chemistry
core/shell nanoparticles
Fluorescent Dyes - pharmacology
histochemistry
histones
Histones - chemistry
Materials Testing
Microscopy, Confocal - methods
Nanoparticles - chemistry
Nanotechnology - methods
Polymers - chemistry
Solubility
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Zusammenfassung:Water‐soluble fluorescent core/shell nanoparticles containing multiple ‐COOH groups are synthesized via atom‐transfer radical polymerization by applying perylenediimide derivatives as the template. This novel dye combines good water‐solubility and attractive optical properties. It specifically stains the cell nucleus by binding to positively charged nuclear proteins (see image).
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.200701107