Covalently PEGylated Carbon Nanotubes with Stealth Character In Vivo

Stealth nanotubes: The stealth character of covalently PEGylated single‐walled nanotubes (SWNTs, indicated by arrows in image) in vivo is studied. The nanotubes exhibit much longer blood‐circulation half‐life in vivo than the previous record for nanotubes and also a low hepatic uptake, vital to uses...

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Veröffentlicht in:	Small (Weinheim an der Bergstrasse, Germany) Germany), 2008-07, Vol.4 (7), p.940-944
Hauptverfasser:	Yang, Sheng-Tao, Fernando, K. A. Shiral, Liu, Jia-Hui, Wang, Jing, Sun, Hong-Fang, Liu, Yuanfang, Chen, Min, Huang, Yipu, Wang, Xin, Wang, Haifang, Sun, Ya-Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Area Under Curve Biocompatible Materials biodistribution Blood Circulation carbon nanotubes Drug Delivery Systems Humans Mice Mice, Inbred C57BL Microscopy, Electron, Transmission Nanoparticles - chemistry Nanotechnology - methods Nanotubes, Carbon - chemistry Polyethylene Glycols - chemistry stealth character Time Factors
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Zusammenfassung:	Stealth nanotubes: The stealth character of covalently PEGylated single‐walled nanotubes (SWNTs, indicated by arrows in image) in vivo is studied. The nanotubes exhibit much longer blood‐circulation half‐life in vivo than the previous record for nanotubes and also a low hepatic uptake, vital to uses in drug‐delivery systems. The benefits are reflected in the observed high tumor uptake of PEGylated SWNTs.
ISSN:	1613-6810 1613-6829
DOI:	10.1002/smll.200700714