Autophagy-Modulating Aminosteroids Isolated from the Sponge Cliona celata

Clionamines A−D (1−4), new aminosteroids that modulate autophagy, have been isolated from South African specimens of the sponge Cliona celata. Clionamine D (4) has an unprecedented spiro bislactone side chain.

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Bibliographische Detailangaben
Veröffentlicht in:	Organic letters 2008-07, Vol.10 (14), p.2959-2962
Hauptverfasser:	Keyzers, Robert A, Daoust, Julie, Davies-Coleman, Michael T, Soest, Rob Van, Balgi, Aruna, Donohue, Elizabeth, Roberge, Michel, Andersen, Raymond J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Marine Biology Molecular Structure Nuclear Magnetic Resonance, Biomolecular Porifera - chemistry Spiro Compounds - chemical synthesis Spiro Compounds - chemistry Steroids - chemical synthesis Steroids - chemistry
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Beschreibung
Zusammenfassung:	Clionamines A−D (1−4), new aminosteroids that modulate autophagy, have been isolated from South African specimens of the sponge Cliona celata. Clionamine D (4) has an unprecedented spiro bislactone side chain.
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol800937u