Up-regulation of Survivin mRNA Might Be a Marker for Non-invasive Detection of Non-small Cell Lung Cancer Rather than for Prognosis

Background: Survivin suppresses programmed cell death and regulates cell division. To evaluate the prognostic importance of the apoptosis inhibitor survivin for non-small cell lung cancer (NSCLC), a study was performed in 64 patients with R0 resections for NSCLC and histopathological stages I-IIIA....

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Veröffentlicht in:	Anticancer research 2008-05, Vol.28 (3A), p.1525-1529
Hauptverfasser:	WARNECKE-EBERZ, Ute, BALDUS, Stephan E, BOLLSCHWEILER, Elfriede, HOELSCHER, Arnulf H, METZGER, Ralf
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biological and medical sciences Biomarkers, Tumor - biosynthesis Biomarkers, Tumor - genetics Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Female Humans Inhibitor of Apoptosis Proteins Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Male Medical sciences Microtubule-Associated Proteins - biosynthesis Microtubule-Associated Proteins - genetics Middle Aged Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Neoplasm Staging Pneumology Prognosis RNA, Messenger - biosynthesis RNA, Messenger - genetics Tumors Tumors of the respiratory system and mediastinum Up-Regulation
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Zusammenfassung:	Background: Survivin suppresses programmed cell death and regulates cell division. To evaluate the prognostic importance of the apoptosis inhibitor survivin for non-small cell lung cancer (NSCLC), a study was performed in 64 patients with R0 resections for NSCLC and histopathological stages I-IIIA. Patients and Methods: Analysis of survivin mRNA expression was performed on 64 paired tumor and normal tissues by quantitative real-time RT-PCR. Results: Survivin expression in tumors (median 3.68, min. 0.19, max. 28.63) was significantly higher (p
ISSN:	0250-7005 1791-7530