Increased serum levels and expression of S100A8/A9 complex in infiltrated neutrophils in atherosclerotic plaque of unstable angina
Background: The S100A8/A9 complex is expressed in a subset of activated neutrophils and macrophages in acute inflammatory lesions associated with various diseases. Objective: To investigate (a) whether serum S100A8/A9 levels are increased in patients with unstable angina (UA); and (b) whether S100A8...
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| Veröffentlicht in: | Heart (British Cardiac Society) 2008-08, Vol.94 (8), p.1002-1007 |
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| creator | Miyamoto, S Ueda, M Ikemoto, M Naruko, T Itoh, A Tamaki, S Nohara, R Terasaki, F Sasayama, S Fujita, M |
| description | Background: The S100A8/A9 complex is expressed in a subset of activated neutrophils and macrophages in acute inflammatory lesions associated with various diseases. Objective: To investigate (a) whether serum S100A8/A9 levels are increased in patients with unstable angina (UA); and (b) whether S100A8/A9 expression is upregulated in coronary atherosclerotic plaques of patients with UA. Design: Serum S100A8/A9 levels in 39 patients with stable angina (SA) and 53 patients with UA were measured. In addition, the presence of the S100A8/A9 complex in directional coronary atherectomy specimens was studied immunohistochemically. Cell types which stain positive for S100A8/A9 were identified by immunodouble staining with neutrophils and macrophages. Results: Mean (SD) serum S100A8/A9 levels were significantly higher in patients with UA than in those with SA (3.25 (3.08) μg/ml vs 0.77 (0.31) μg/ml, p |
| doi_str_mv | 10.1136/hrt.2007.121640 |
| format | Article |
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Objective: To investigate (a) whether serum S100A8/A9 levels are increased in patients with unstable angina (UA); and (b) whether S100A8/A9 expression is upregulated in coronary atherosclerotic plaques of patients with UA. Design: Serum S100A8/A9 levels in 39 patients with stable angina (SA) and 53 patients with UA were measured. In addition, the presence of the S100A8/A9 complex in directional coronary atherectomy specimens was studied immunohistochemically. Cell types which stain positive for S100A8/A9 were identified by immunodouble staining with neutrophils and macrophages. Results: Mean (SD) serum S100A8/A9 levels were significantly higher in patients with UA than in those with SA (3.25 (3.08) μg/ml vs 0.77 (0.31) μg/ml, p<0.05). In patients with UA, immunodouble staining clearly showed that the S100A8/A9 complex was expressed in infiltrated neutrophils and occasional macrophages. The S100A8/A9-positive area was significantly higher in UA than in SA (mean (SD) 18.3 (14.2)% vs 1.3 (2.4)%, respectively, p<0.001). Conclusions: The S100A8/A9 complex may be involved in the inflammatory process of coronary atherosclerotic plaques in patients with UA.</description><identifier>ISSN: 1355-6037</identifier><identifier>EISSN: 1468-201X</identifier><identifier>DOI: 10.1136/hrt.2007.121640</identifier><identifier>PMID: 18308864</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and British Cardiovascular Society</publisher><subject>Acute coronary syndromes ; Aged ; Angina Pectoris - diagnosis ; Angina, Unstable - diagnosis ; Angina, Unstable - etiology ; Angina, Unstable - metabolism ; Atherosclerosis (general aspects, experimental research) ; Binding sites ; Biological and medical sciences ; Biomarkers - blood ; Blood and lymphatic vessels ; C-Reactive Protein - analysis ; Calgranulin A - blood ; Calgranulin A - metabolism ; Calgranulin B - blood ; Calgranulin B - metabolism ; Cardiology. Vascular system ; Cardiovascular disease ; Cohort Studies ; Coronary Artery Disease - complications ; Coronary Artery Disease - diagnosis ; Coronary Artery Disease - metabolism ; Coronary heart disease ; Diabetes ; Diagnosis, Differential ; Female ; Fibrin Fibrinogen Degradation Products - analysis ; Heart ; Heart attacks ; Humans ; Hypertension ; Immunoenzyme Techniques ; Inflammation ; Male ; Medical sciences ; Middle Aged ; Neutrophil Infiltration ; Neutrophils ; Neutrophils - metabolism ; Polyclonal antibodies ; Smooth muscle</subject><ispartof>Heart (British Cardiac Society), 2008-08, Vol.94 (8), p.1002-1007</ispartof><rights>2008 BMJ Publishing Group and British Cardiovascular Society</rights><rights>2008 INIST-CNRS</rights><rights>Copyright: 2008 2008 BMJ Publishing Group and British Cardiovascular Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b523t-10bdfd8e8c28d8d8a2ab49847f3e81a66eaddc10d2a47985e58011c777f93e823</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://heart.bmj.com/content/94/8/1002.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://heart.bmj.com/content/94/8/1002.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,776,780,3183,23552,27903,27904,77346,77377</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20492063$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18308864$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miyamoto, S</creatorcontrib><creatorcontrib>Ueda, M</creatorcontrib><creatorcontrib>Ikemoto, M</creatorcontrib><creatorcontrib>Naruko, T</creatorcontrib><creatorcontrib>Itoh, A</creatorcontrib><creatorcontrib>Tamaki, S</creatorcontrib><creatorcontrib>Nohara, R</creatorcontrib><creatorcontrib>Terasaki, F</creatorcontrib><creatorcontrib>Sasayama, S</creatorcontrib><creatorcontrib>Fujita, M</creatorcontrib><title>Increased serum levels and expression of S100A8/A9 complex in infiltrated neutrophils in atherosclerotic plaque of unstable angina</title><title>Heart (British Cardiac Society)</title><addtitle>Heart</addtitle><description>Background: The S100A8/A9 complex is expressed in a subset of activated neutrophils and macrophages in acute inflammatory lesions associated with various diseases. Objective: To investigate (a) whether serum S100A8/A9 levels are increased in patients with unstable angina (UA); and (b) whether S100A8/A9 expression is upregulated in coronary atherosclerotic plaques of patients with UA. Design: Serum S100A8/A9 levels in 39 patients with stable angina (SA) and 53 patients with UA were measured. In addition, the presence of the S100A8/A9 complex in directional coronary atherectomy specimens was studied immunohistochemically. Cell types which stain positive for S100A8/A9 were identified by immunodouble staining with neutrophils and macrophages. Results: Mean (SD) serum S100A8/A9 levels were significantly higher in patients with UA than in those with SA (3.25 (3.08) μg/ml vs 0.77 (0.31) μg/ml, p<0.05). In patients with UA, immunodouble staining clearly showed that the S100A8/A9 complex was expressed in infiltrated neutrophils and occasional macrophages. The S100A8/A9-positive area was significantly higher in UA than in SA (mean (SD) 18.3 (14.2)% vs 1.3 (2.4)%, respectively, p<0.001). Conclusions: The S100A8/A9 complex may be involved in the inflammatory process of coronary atherosclerotic plaques in patients with UA.</description><subject>Acute coronary syndromes</subject><subject>Aged</subject><subject>Angina Pectoris - diagnosis</subject><subject>Angina, Unstable - diagnosis</subject><subject>Angina, Unstable - etiology</subject><subject>Angina, Unstable - metabolism</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Binding sites</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Blood and lymphatic vessels</subject><subject>C-Reactive Protein - analysis</subject><subject>Calgranulin A - blood</subject><subject>Calgranulin A - metabolism</subject><subject>Calgranulin B - blood</subject><subject>Calgranulin B - metabolism</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular disease</subject><subject>Cohort Studies</subject><subject>Coronary Artery Disease - complications</subject><subject>Coronary Artery Disease - diagnosis</subject><subject>Coronary Artery Disease - metabolism</subject><subject>Coronary heart disease</subject><subject>Diabetes</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Fibrin Fibrinogen Degradation Products - analysis</subject><subject>Heart</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Immunoenzyme Techniques</subject><subject>Inflammation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neutrophil Infiltration</subject><subject>Neutrophils</subject><subject>Neutrophils - metabolism</subject><subject>Polyclonal antibodies</subject><subject>Smooth muscle</subject><issn>1355-6037</issn><issn>1468-201X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkcuP0zAQxiMEYh9w5oYiIfaAlHbsJLZzrCoeCwUk3jfLcSY0xXGCnaBy5S9nqlaLxGVly2Npft94xl-SPGKwYCwXy22YFhxALhhnooA7yTkrhMo4sG936Z6XZSYgl2fJRYw7ACgqJe4nZ0zloJQozpM_194GNBGbNGKY-9ThL3QxNb5JcT8GjLEbfDq06UcGsFLLVZXaoR8d7tPO0247NwUzkd7jPIVh3HYkp5SZthiGaB2dU2fT0ZmfMx4qzT5OpnZIj3zvvHmQ3GuNi_jwFC-Tzy-ef1q_yjbvX16vV5usLnk-ZQzqpm0UKstVQ8twU9M4hWxzVMwIgaZpLIOGm0JWqsRSAWNWStlWRPD8Mrk61h3DQJ3ESfddtOic8TjMUYsqZ8BVcSvIQckCZEXgk__A3TAHT0NoJhWosgSpiFoeKUvfEQO2egxdb8JvzUAfXNTkoj64qI8ukuLxqe5c99j840-2EfD0BJhojWuD8baLNxwnnzmInLjsyHVxwv1N3oQfWshclvrdl7X-wNTXN5vXb_WG-GdHvu53t3b5F0xpwjI</recordid><startdate>20080801</startdate><enddate>20080801</enddate><creator>Miyamoto, S</creator><creator>Ueda, M</creator><creator>Ikemoto, M</creator><creator>Naruko, T</creator><creator>Itoh, A</creator><creator>Tamaki, S</creator><creator>Nohara, R</creator><creator>Terasaki, F</creator><creator>Sasayama, S</creator><creator>Fujita, M</creator><general>BMJ Publishing Group Ltd and British Cardiovascular Society</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7QP</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20080801</creationdate><title>Increased serum levels and expression of S100A8/A9 complex in infiltrated neutrophils in atherosclerotic plaque of unstable angina</title><author>Miyamoto, S ; Ueda, M ; Ikemoto, M ; Naruko, T ; Itoh, A ; Tamaki, S ; Nohara, R ; Terasaki, F ; Sasayama, S ; Fujita, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b523t-10bdfd8e8c28d8d8a2ab49847f3e81a66eaddc10d2a47985e58011c777f93e823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Acute coronary syndromes</topic><topic>Aged</topic><topic>Angina Pectoris - diagnosis</topic><topic>Angina, Unstable - diagnosis</topic><topic>Angina, Unstable - etiology</topic><topic>Angina, Unstable - metabolism</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Binding sites</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Blood and lymphatic vessels</topic><topic>C-Reactive Protein - analysis</topic><topic>Calgranulin A - blood</topic><topic>Calgranulin A - metabolism</topic><topic>Calgranulin B - blood</topic><topic>Calgranulin B - metabolism</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular disease</topic><topic>Cohort Studies</topic><topic>Coronary Artery Disease - complications</topic><topic>Coronary Artery Disease - diagnosis</topic><topic>Coronary Artery Disease - metabolism</topic><topic>Coronary heart disease</topic><topic>Diabetes</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>Fibrin Fibrinogen Degradation Products - analysis</topic><topic>Heart</topic><topic>Heart attacks</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Immunoenzyme Techniques</topic><topic>Inflammation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neutrophil Infiltration</topic><topic>Neutrophils</topic><topic>Neutrophils - metabolism</topic><topic>Polyclonal antibodies</topic><topic>Smooth muscle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miyamoto, S</creatorcontrib><creatorcontrib>Ueda, M</creatorcontrib><creatorcontrib>Ikemoto, M</creatorcontrib><creatorcontrib>Naruko, T</creatorcontrib><creatorcontrib>Itoh, A</creatorcontrib><creatorcontrib>Tamaki, S</creatorcontrib><creatorcontrib>Nohara, R</creatorcontrib><creatorcontrib>Terasaki, F</creatorcontrib><creatorcontrib>Sasayama, S</creatorcontrib><creatorcontrib>Fujita, M</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health Medical collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Heart (British Cardiac Society)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miyamoto, S</au><au>Ueda, M</au><au>Ikemoto, M</au><au>Naruko, T</au><au>Itoh, A</au><au>Tamaki, S</au><au>Nohara, R</au><au>Terasaki, F</au><au>Sasayama, S</au><au>Fujita, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased serum levels and expression of S100A8/A9 complex in infiltrated neutrophils in atherosclerotic plaque of unstable angina</atitle><jtitle>Heart (British Cardiac Society)</jtitle><addtitle>Heart</addtitle><date>2008-08-01</date><risdate>2008</risdate><volume>94</volume><issue>8</issue><spage>1002</spage><epage>1007</epage><pages>1002-1007</pages><issn>1355-6037</issn><eissn>1468-201X</eissn><abstract>Background: The S100A8/A9 complex is expressed in a subset of activated neutrophils and macrophages in acute inflammatory lesions associated with various diseases. Objective: To investigate (a) whether serum S100A8/A9 levels are increased in patients with unstable angina (UA); and (b) whether S100A8/A9 expression is upregulated in coronary atherosclerotic plaques of patients with UA. Design: Serum S100A8/A9 levels in 39 patients with stable angina (SA) and 53 patients with UA were measured. In addition, the presence of the S100A8/A9 complex in directional coronary atherectomy specimens was studied immunohistochemically. Cell types which stain positive for S100A8/A9 were identified by immunodouble staining with neutrophils and macrophages. Results: Mean (SD) serum S100A8/A9 levels were significantly higher in patients with UA than in those with SA (3.25 (3.08) μg/ml vs 0.77 (0.31) μg/ml, p<0.05). In patients with UA, immunodouble staining clearly showed that the S100A8/A9 complex was expressed in infiltrated neutrophils and occasional macrophages. The S100A8/A9-positive area was significantly higher in UA than in SA (mean (SD) 18.3 (14.2)% vs 1.3 (2.4)%, respectively, p<0.001). Conclusions: The S100A8/A9 complex may be involved in the inflammatory process of coronary atherosclerotic plaques in patients with UA.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and British Cardiovascular Society</pub><pmid>18308864</pmid><doi>10.1136/hrt.2007.121640</doi><tpages>6</tpages></addata></record> |
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| subjects | Acute coronary syndromes Aged Angina Pectoris - diagnosis Angina, Unstable - diagnosis Angina, Unstable - etiology Angina, Unstable - metabolism Atherosclerosis (general aspects, experimental research) Binding sites Biological and medical sciences Biomarkers - blood Blood and lymphatic vessels C-Reactive Protein - analysis Calgranulin A - blood Calgranulin A - metabolism Calgranulin B - blood Calgranulin B - metabolism Cardiology. Vascular system Cardiovascular disease Cohort Studies Coronary Artery Disease - complications Coronary Artery Disease - diagnosis Coronary Artery Disease - metabolism Coronary heart disease Diabetes Diagnosis, Differential Female Fibrin Fibrinogen Degradation Products - analysis Heart Heart attacks Humans Hypertension Immunoenzyme Techniques Inflammation Male Medical sciences Middle Aged Neutrophil Infiltration Neutrophils Neutrophils - metabolism Polyclonal antibodies Smooth muscle |
| title | Increased serum levels and expression of S100A8/A9 complex in infiltrated neutrophils in atherosclerotic plaque of unstable angina |
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