Increased serum levels and expression of S100A8/A9 complex in infiltrated neutrophils in atherosclerotic plaque of unstable angina

Background: The S100A8/A9 complex is expressed in a subset of activated neutrophils and macrophages in acute inflammatory lesions associated with various diseases. Objective: To investigate (a) whether serum S100A8/A9 levels are increased in patients with unstable angina (UA); and (b) whether S100A8...

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Veröffentlicht in:	Heart (British Cardiac Society) 2008-08, Vol.94 (8), p.1002-1007
Hauptverfasser:	Miyamoto, S, Ueda, M, Ikemoto, M, Naruko, T, Itoh, A, Tamaki, S, Nohara, R, Terasaki, F, Sasayama, S, Fujita, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute coronary syndromes Aged Angina Pectoris - diagnosis Angina, Unstable - diagnosis Angina, Unstable - etiology Angina, Unstable - metabolism Atherosclerosis (general aspects, experimental research) Binding sites Biological and medical sciences Biomarkers - blood Blood and lymphatic vessels C-Reactive Protein - analysis Calgranulin A - blood Calgranulin A - metabolism Calgranulin B - blood Calgranulin B - metabolism Cardiology. Vascular system Cardiovascular disease Cohort Studies Coronary Artery Disease - complications Coronary Artery Disease - diagnosis Coronary Artery Disease - metabolism Coronary heart disease Diabetes Diagnosis, Differential Female Fibrin Fibrinogen Degradation Products - analysis Heart Heart attacks Humans Hypertension Immunoenzyme Techniques Inflammation Male Medical sciences Middle Aged Neutrophil Infiltration Neutrophils Neutrophils - metabolism Polyclonal antibodies Smooth muscle
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Zusammenfassung:	Background: The S100A8/A9 complex is expressed in a subset of activated neutrophils and macrophages in acute inflammatory lesions associated with various diseases. Objective: To investigate (a) whether serum S100A8/A9 levels are increased in patients with unstable angina (UA); and (b) whether S100A8/A9 expression is upregulated in coronary atherosclerotic plaques of patients with UA. Design: Serum S100A8/A9 levels in 39 patients with stable angina (SA) and 53 patients with UA were measured. In addition, the presence of the S100A8/A9 complex in directional coronary atherectomy specimens was studied immunohistochemically. Cell types which stain positive for S100A8/A9 were identified by immunodouble staining with neutrophils and macrophages. Results: Mean (SD) serum S100A8/A9 levels were significantly higher in patients with UA than in those with SA (3.25 (3.08) μg/ml vs 0.77 (0.31) μg/ml, p
ISSN:	1355-6037 1468-201X
DOI:	10.1136/hrt.2007.121640