Simultaneous estimation of atorvastatin and ramipril by RP-HPLC and spectroscopy

A number of analytical methods were reported for the estimation of atorvastatin and ramipril from their individual dosage forms or in combination with other drugs (Valiyare, 2004; Vachareau and Neirinck, 2000). Here successful reverse phase-high performance liquid chromatographic method and spectros...

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Veröffentlicht in:	Pakistan journal of pharmaceutical sciences 2008-07, Vol.21 (3), p.282-284
Hauptverfasser:	Joseph, Lincy, George, Mathew, Rao B, Venkata Ranga
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin-Converting Enzyme Inhibitors - analysis Antihypertensive drugs Atorvastatin Calcium Capsules Cardiovascular agents Chromatography Chromatography, High Pressure Liquid Drug Combinations Heptanoic Acids - analysis Hydroxymethylglutaryl-CoA Reductase Inhibitors - analysis Least-Squares Analysis Pyrroles - analysis Ramipril - analysis Reproducibility of Results Spectrophotometry, Ultraviolet
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Beschreibung
Zusammenfassung:	A number of analytical methods were reported for the estimation of atorvastatin and ramipril from their individual dosage forms or in combination with other drugs (Valiyare, 2004; Vachareau and Neirinck, 2000). Here successful reverse phase-high performance liquid chromatographic method and spectroscopic methods developed then validated for the analysis of combined dosage form of atorvastatin and ramipril. Individual lambda-max for atorvastatin is 247 n.m and that of ramipril is 208 n.m. They intercept at 215 n.m which is fixed as wavelength for reverse phase-high performance liquid chromatographic method.
ISSN:	1011-601X