Hypolipidemic properties of a diphenyl-methylen-ethylamine derivative with affinity for β 3-adrenoceptors in a model of hypercholesterolemia
β 3-Adrenergic agonists have been proposed as potential new drugs for the treatment of diabetes and/or obesity therapy, because of the hypoglycemic and lipolytic effects found with some of these compounds. Moreover, their application in other therapeutic areas such as hypercholesterolemia and athero...
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| Veröffentlicht in: | Farmaco (Società chimica italiana : 1989) 1999-10, Vol.54 (10), p.710-712 |
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| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | β
3-Adrenergic agonists have been proposed as potential new drugs for the treatment of diabetes and/or obesity therapy, because of the hypoglycemic and lipolytic effects found with some of these compounds. Moreover, their application in other therapeutic areas such as hypercholesterolemia and atherosclerosis has been suggested. This experimental trial was conducted to assess the effects of Trecadrine, a new molecule with affinity for β
3-adrenoceptors, on a model of hypercholesterolemia in rats, and also to explore a possible beneficial role of these agents in lipid disturbances therapy. The results indicated a marked reduction in serum triglyceride levels (−40%;
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| ISSN: | 0014-827X 1879-0569 |
| DOI: | 10.1016/S0014-827X(99)00087-7 |