Advanced glycation index and its association with severity of diabetic retinopathy in type 2 diabetic subjects

Abstract Background This study investigates the association of advanced glycation index (AGI), a simple assay to detect advanced glycation endproducts (AGEs) in serum, with severity of diabetic retinopathy (DR) in type 2 diabetic subjects. Methods The study included 188 type 2 diabetic subjects with...

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Veröffentlicht in:	Journal of diabetes and its complications 2008-07, Vol.22 (4), p.261-266
Hauptverfasser:	Anitha, Balaji, Sampathkumar, Rangasamy, Balasubramanyam, Muthuswamy, Rema, Mohan
Format:	Artikel
Sprache:	eng
Schlagworte:	AGE Aged AGI Biomarkers Cholesterol Diabetes Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications Diabetic retinopathy Diabetic Retinopathy - blood Endocrinology & Metabolism Epidemiology Female Gene expression Glycated Hemoglobin A - analysis Humans Hyperglycemia India - epidemiology Male Medical imaging Middle Aged Prognosis Regression analysis Severity of Illness Index Type 2 diabetes
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Zusammenfassung:	Abstract Background This study investigates the association of advanced glycation index (AGI), a simple assay to detect advanced glycation endproducts (AGEs) in serum, with severity of diabetic retinopathy (DR) in type 2 diabetic subjects. Methods The study included 188 type 2 diabetic subjects without DR, 153 subjects with nonproliferative DR, 41 subjects with proliferative DR, and 188 control participants. Serum levels of AGEs were monitored with a spectrofluorimeter by recording Maillard-specific fluorescence. Results AGI values increased with severity of DR (analysis of variance, P
ISSN:	1056-8727 1873-460X
DOI:	10.1016/j.jdiacomp.2007.05.005