Antiviral and Anticoagulant Activities of a Water-Soluble Fraction of the Marine Diatom Haslea ostrearia

Abstract: A water-soluble fraction from the marine diatom HASLEA OSTREARIA was capable to inhibit the IN VITRO replication of HSV-1 in Vero cells with 50 % inhibitory concentration (EC 50 ) of 14 μg/ml at a multiplicity of infection of 0.01 ID 50 /cells. In addition, this fraction delayed the HIV-1-...

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Veröffentlicht in:	Planta medica 1999-10, Vol.65 (7), p.604-609
Hauptverfasser:	Bergé, J.-P., Bourgougnon, N., Alban, S., Pojer, F., Billaudel, S., Chermann, J.-C., Robert, J. M., Franz, G.
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Animals Anti-HIV Agents - chemistry Anti-HIV Agents - pharmacology Anticoagulants - chemistry Anticoagulants - pharmacology Antiviral Agents - chemistry Antiviral Agents - pharmacology Biological and medical sciences Carbohydrates - chemistry Carbohydrates - pharmacology Cell Line Cercopithecus aethiops Diatoms - chemistry General pharmacology Herpesvirus 1, Human - drug effects Humans Medical sciences Original Paper Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - chemistry Plant Extracts - pharmacology Vero Cells
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Zusammenfassung:	Abstract: A water-soluble fraction from the marine diatom HASLEA OSTREARIA was capable to inhibit the IN VITRO replication of HSV-1 in Vero cells with 50 % inhibitory concentration (EC 50 ) of 14 μg/ml at a multiplicity of infection of 0.01 ID 50 /cells. In addition, this fraction delayed the HIV-1-induced syncitia formation on MT4 cells. At concentrations up to 200 μg/ml, no cytotoxicity was observed for both the Vero and MT4 cells. The fraction only inhibited the blood coagulation process at concentrations considerably exceeding the EC 50 .
ISSN:	0032-0943 1439-0221
DOI:	10.1055/s-1999-14032