Synthesis and relative binding affinity to steroid receptors and antiproliferative activity on MCF-7 cells of 2,3-disubstituted indenes

The study of the relative binding affinity of a set of 2,3-disubstituted indenes to the receptors of steroid hormones indicates a weak effect of some derivatives on estrogen, progesterone and androgen receptors. The antiproliferative effect on human MCF-7 cells also shows a weak activity for three d...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Farmaco (Società chimica italiana : 1989) 1999-10, Vol.54 (10), p.678-683
Hauptverfasser:	Kirkiacharian, Serge, Koutsourakis, Pantelis G, Philibert, Daniel, Bouchoux, Francoise, Van De Velde, Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Antiproliferative activity Binding affinity Biological and medical sciences Breast Neoplasms - drug therapy Breast Neoplasms - pathology Female General aspects Humans Indenes - chemical synthesis Indenes - metabolism Indenes - pharmacology Medical sciences Pharmacology. Drug treatments Receptors, Steroid - metabolism Steroid receptor Structure-Activity Relationship Tumor Cells, Cultured
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The study of the relative binding affinity of a set of 2,3-disubstituted indenes to the receptors of steroid hormones indicates a weak effect of some derivatives on estrogen, progesterone and androgen receptors. The antiproliferative effect on human MCF-7 cells also shows a weak activity for three derivatives.
ISSN:	0014-827X 1879-0569
DOI:	10.1016/S0014-827X(99)00080-4